{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T08:52:41Z","timestamp":1788079961960,"version":"build-2784847793"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,1,19]],"date-time":"2016-01-19T00:00:00Z","timestamp":1453161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Amiodarone is an anti\u2010arrhythmic drug that commonly affects the thyroid, causing hypothyroidism or thyrotoxicosis. Amiodarone\u2010induced thyrotoxicosis (<jats:styled-content style=\"fixed-case\">AIT<\/jats:styled-content>) is caused by excessive thyroid hormone biosynthesis in response to iodine load in autonomously functioning thyroid glands with pre\u2010existing nodular goitre or underlying Graves' disease (type 1 or <jats:styled-content style=\"fixed-case\">AIT<\/jats:styled-content> 1), or by a destructive thyroiditis typically occurring in normal glands (type 2 or <jats:styled-content style=\"fixed-case\">AIT<\/jats:styled-content> 2). Indeterminate or mixed forms are also recognized. The distinction is clinically useful as <jats:styled-content style=\"fixed-case\">AIT<\/jats:styled-content> 1 is treated predominantly with thionamides, whereas <jats:styled-content style=\"fixed-case\">AIT<\/jats:styled-content> 2 is managed with glucocorticoids. We review the tools used to differentiate type 1 from type 2 thyrotoxicosis, with specific reference to the imaging modalities used.<\/jats:p>","DOI":"10.1111\/cen.12988","type":"journal-article","created":{"date-parts":[[2015,12,8]],"date-time":"2015-12-08T18:24:33Z","timestamp":1449599073000},"page":"172-176","source":"Crossref","is-referenced-by-count":18,"title":["Thyrotoxicosis associated with the use of amiodarone: the utility of ultrasound in patient management"],"prefix":"10.1111","volume":"84","author":[{"given":"Aikaterini","family":"Theodoraki","sequence":"first","affiliation":[{"name":"Department of Endocrinology Royal Free London NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark P. J.","family":"Vanderpump","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Royal Free London NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2008.03350.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.22.2.240"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-62-3-563"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-126-1-199701010-00009"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.8.2930"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-0940"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-08-0348"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.46.443"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2007.02920.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.02122"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1445-5994.2003.00463.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0300-0664.2001.01457.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2009.218"},{"key":"e_1_2_9_15_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1210\/jcem.86.1.7119","article-title":"Amiodarone\u2010induced thyrotoxicosis","volume":"86","author":"Daniels G.H.","year":"2001","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.1997.7.541"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.78.2.423"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-0180"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2008.03268.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2004.02119.x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-002-0811-8"},{"key":"e_1_2_9_22_1","first-page":"393","article-title":"Comparison of technetium\u201099m and iodine\u2010123 imaging of thyroid nodules: correlation with pathologic findings","volume":"31","author":"Kusic Z.","year":"1990","journal-title":"Journal of Nuclear Medicine"},{"key":"e_1_2_9_23_1","first-page":"1646","article-title":"Effect of mitochondrial and plasma membrane potentials on accumulation of hexakis (2\u2010methoxyisobutylisonitrile) technetium(I) in cultured mouse fibroblasts","volume":"31","author":"Chiu M.L.","year":"1990","journal-title":"Journal of Nuclear Medicine"},{"key":"e_1_2_9_24_1","first-page":"167","article-title":"Radioactive iodine thyroid uptake in patients with amiodarone\u2010iodine\u2010induced thyroid dysfunction","volume":"119","author":"Martino E.","year":"1988","journal-title":"Acta endocrinologica"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03347021"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841850701342138"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-27302011000700009"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNM.0000000000000260"},{"key":"e_1_2_9_29_1","first-page":"29","article-title":"Appearance of thyroid diseases using colour\u2010coded duplex sonography","volume":"9","author":"Fobbe F.","year":"1989","journal-title":"European Journal of Radiology"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1430339"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1363282"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050051"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcen.12988","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.12988","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T06:16:02Z","timestamp":1695536162000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.12988"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,19]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1111\/cen.12988"],"URL":"https:\/\/doi.org\/10.1111\/cen.12988","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,19]]}}}