{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T18:00:22Z","timestamp":1722016822702},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,1,29]],"date-time":"2016-01-29T00:00:00Z","timestamp":1454025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["171202014"],"award-info":[{"award-number":["171202014"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Context<\/jats:title><jats:p>Thyroid dysfunction is thought to be associated with stillbirth. Therefore, thyroid function is often recommended in the diagnostic investigations for stillbirth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to evaluate the added value of thyroid function testing in the diagnostic investigations for stillbirth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and patients<\/jats:title><jats:p>A nationwide multicentre prospective cohort study in 1025 women who suffered stillbirth &gt;20 weeks of gestation performed between 2002 and 2008. In each woman, an extensive diagnostic work\u2010up was performed, including placental examination and autopsy. <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FT<\/jats:styled-content>4 values below the 2\u00b75th percentile or above the 97\u00b75th percentile according local laboratory reference values were regarded as abnormal. Women with a history of thyroid disease were evaluated separately.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Thyroid function abnormalities in women with stillbirth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 1025 included women, 21 had a history of thyroid disease (2%). In the 875 with <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FT<\/jats:styled-content>4 results and no history of thyroid disease, 10% had hypothyroxinemia, 4\u00b76% subclinical hypothyroidism, 1\u00b76% overt hypothyroidism and 1\u00b75% subclinical hyperthyroidism. Women with a subclinical hyperthyroidism more often had a foetal death caused by foetal hydrops: 23% <jats:italic>vs<\/jats:italic> 2\u00b79% (adjusted <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 10\u00b73, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2\u00b75\u201342).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Women with a stillbirth had a slightly higher prevalence of overt hypothyroidism, subclinical hypothyroidism and hypothyroxinaemia compared to previous studies on thyroid dysfunction in pregnant women. Given the absence of a strong associations with the cause of stillbirth, and no demonstrated beneficial effects of treating thyroid dysfunction in these women, routine screening after stillbirth is not justified.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13002","type":"journal-article","created":{"date-parts":[[2015,12,15]],"date-time":"2015-12-15T12:33:48Z","timestamp":1450182828000},"page":"291-298","source":"Crossref","is-referenced-by-count":10,"title":["Thyroid function testing in women who had a stillbirth"],"prefix":"10.1111","volume":"85","author":[{"given":"Janna W.","family":"Nijkamp","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology University Medical Center Groningen University of Groningen Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fleurisca J.","family":"Korteweg","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Martini Hospital Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henk","family":"Groen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University Medical Center Groningen University of Groningen Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albertus","family":"Timmer","sequence":"additional","affiliation":[{"name":"Department of Pathology and Medical Biology University Medical Center Groningen University of Groningen Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerrit","family":"Van Den Berg","sequence":"additional","affiliation":[{"name":"Department of Endocrinology University Medical Center Groningen University of Groningen Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick M.","family":"Bossuyt","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology &amp; 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