{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T21:29:59Z","timestamp":1792186199510,"version":"4.4.0"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,1,29]],"date-time":"2016-01-29T00:00:00Z","timestamp":1454025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Vice chancellor for Research, AUMS"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Limited data are available for evaluating the effects of oral carnitine supplementation on weight loss and metabolic profiles of women with polycystic ovary syndrome (<jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>). This study was designed to determine the effects of oral carnitine supplementation on weight loss, and glycaemic and lipid profiles in women with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design, Patients and Measurements<\/jats:title><jats:p>In a prospective, randomized, double\u2010blind, placebo\u2010controlled trial, 60 overweight patients diagnosed with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> were randomized to receive either 250 mg carnitine supplements (<jats:italic>n<\/jats:italic> = 30) or placebo (<jats:italic>n<\/jats:italic> = 30) for 12 weeks. Fasting blood samples were obtained at the beginning and the end of the study to quantify parameters of glucose homoeostasis and lipid concentrations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At the end of the 12 weeks, taking carnitine supplements resulted in a significant reduction in weight (\u22122\u00b77 \u00b1 1\u00b75 <jats:italic>vs<\/jats:italic> +0\u00b71 \u00b1 1\u00b78 kg, <jats:italic>P<\/jats:italic> &lt; 0\u00b7001), <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> (\u22121\u00b71 \u00b1 0\u00b76 <jats:italic>vs<\/jats:italic> +0\u00b71 \u00b1 0\u00b77 kg\/m<jats:sup>2<\/jats:sup>, <jats:italic>P<\/jats:italic> &lt; 0\u00b7001), waist circumference (<jats:styled-content style=\"fixed-case\">WC<\/jats:styled-content>) (\u22122\u00b70 \u00b1 1\u00b73 <jats:italic>vs<\/jats:italic> \u22120\u00b73 \u00b1 2\u00b70 cm, <jats:italic>P<\/jats:italic> &lt; 0\u00b7001) and hip circumference (<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>) (\u22122\u00b75 \u00b1 1\u00b75 <jats:italic>vs<\/jats:italic> \u22120\u00b73 \u00b1 1\u00b78 cm, <jats:italic>P<\/jats:italic> &lt; 0\u00b7001) compared with placebo. In addition, compared with placebo, carnitine administration in women with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> led to a significant reduction in fasting plasma glucose (\u22120\u00b738 \u00b1 0\u00b736 <jats:italic>vs<\/jats:italic> +0\u00b711 \u00b1 0\u00b797 mmol\/l, <jats:italic>P<\/jats:italic> = 0\u00b701), serum insulin levels (\u221214\u00b739 \u00b1 25\u00b780 <jats:italic>vs<\/jats:italic> +3\u00b701 \u00b1 37\u00b725 pmol\/l, <jats:italic>P<\/jats:italic> = 0\u00b704), homoeostasis model of assessment\u2010insulin resistance (\u22120\u00b761 \u00b1 1\u00b703 <jats:italic>vs<\/jats:italic> +0\u00b711 \u00b1 1\u00b743, <jats:italic>P<\/jats:italic> = 0\u00b704) and dehydroepiandrosterone sulphate (\u22123\u00b764 \u00b1 7\u00b700 <jats:italic>vs<\/jats:italic> \u22120\u00b759 \u00b1 3\u00b720 \u03bcmol\/l, <jats:italic>P<\/jats:italic> = 0\u00b703).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Overall, 12 weeks of 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