{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:18:31Z","timestamp":1792451911767,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,2,16]],"date-time":"2016-02-16T00:00:00Z","timestamp":1455580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Mutations of the genes encoding succinate dehydrogenase B and D (<jats:styled-content style=\"fixed-case\">SDHB<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> SDHD<\/jats:styled-content>) are associated with highly penetrant phenotypes, including paragangliomas and phaeochromocytomas. Patients with these mutations require lifelong surveillance; however, there is currently ambiguity regarding the optimal screening regimen. We sought to determine the utility of fluorodeoxyglucose (18F) positron emission tomography (18F\u2010<jats:styled-content style=\"fixed-case\">FDG PET<\/jats:styled-content>) imaging, compared to other modalities for detecting <jats:styled-content style=\"fixed-case\">SDHB<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SDHD<\/jats:styled-content> mutation\u2010related lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A retrospective audit of patients with <jats:styled-content style=\"fixed-case\">SDHB<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">SDHD<\/jats:styled-content> mutation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>All adult patients with confirmed <jats:styled-content style=\"fixed-case\">SDHB<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SDHD<\/jats:styled-content> mutations who underwent 18F\u2010<jats:styled-content style=\"fixed-case\">FDG PET<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> at our institution between 1 July 2011 and 30 May 2015.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>18F\u2010<jats:styled-content style=\"fixed-case\">FDG PET<\/jats:styled-content>\/computed tomography (<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>) performed during surveillance of patients with <jats:styled-content style=\"fixed-case\">SDHB<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SDHD<\/jats:styled-content> mutations. Lesion numbers and locations detected by 18F\u2010<jats:styled-content style=\"fixed-case\">FDG PET<\/jats:styled-content> were compared to those identified on the <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> component, as well as other imaging modalities and histology when available.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010one 18F\u2010<jats:styled-content style=\"fixed-case\">FDG PET<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> studies were completed on 22 patients. For <jats:styled-content style=\"fixed-case\">SDHB<\/jats:styled-content> (20 patients), there were five positive and 21 negative studies. There were no false\u2010negative 18F\u2010<jats:styled-content style=\"fixed-case\">FDG PET<\/jats:styled-content> studies. Positive 18F\u2010<jats:styled-content style=\"fixed-case\">FDG PET<\/jats:styled-content> findings correlated with magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> and [68 Ga]\u2010<jats:styled-content style=\"fixed-case\">DOTA<\/jats:styled-content>(0)\u2010Tyr(3)\u2010octreotate (68 Ga <jats:styled-content style=\"fixed-case\">DOTATATE PET<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>) imaging with no missed lesions; the only potential false\u2010positive result relating to nonspecific postoperative changes (sensitivity 100\u00b70%, specificity 95\u00b75%).<\/jats:p><jats:p>For <jats:styled-content style=\"fixed-case\">SDHD<\/jats:styled-content> (two patients), lesions were detected on 18F\u2010<jats:styled-content style=\"fixed-case\">FDG PET<\/jats:styled-content> and correlated with other imaging in three of five studies. Metastatic lesions were incompletely visualized on 18F\u2010<jats:styled-content style=\"fixed-case\">FDG PET<\/jats:styled-content> but were detected on the noncontrast fusion <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>18F\u2010<jats:styled-content style=\"fixed-case\">FDG PET<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> is suitable for detecting <jats:styled-content style=\"fixed-case\">SDHB<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SDHD<\/jats:styled-content> mutation\u2010related lesions and may be considered effective for periodic surveillance of patients with these mutations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13020","type":"journal-article","created":{"date-parts":[[2016,1,18]],"date-time":"2016-01-18T13:38:04Z","timestamp":1453124284000},"page":"172-179","source":"Crossref","is-referenced-by-count":15,"title":["Utility of <scp>FDG<\/scp>\u2010<scp>PET<\/scp> imaging in screening for succinate dehydrogenase B and D mutation\u2010related lesions"],"prefix":"10.1111","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6929-7266","authenticated-orcid":false,"given":"E.R.","family":"Kornaczewski","sequence":"first","affiliation":[{"name":"Department of Diabetes &amp; Endocrinology Royal Hobart Hospital Hobart TAS Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.P.","family":"Pointon","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Royal Hobart Hospital Hobart TAS Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.R.","family":"Burgess","sequence":"additional","affiliation":[{"name":"Department of Diabetes &amp; Endocrinology Royal Hobart Hospital Hobart TAS Australia"},{"name":"School of Medicine University of Tasmania Hobart TAS Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1498"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2011.09.026"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-2975"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-11-0170"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2009.02111.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2004.11.022"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2013-1549"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-13-0398"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi227"},{"key":"e_1_2_7_11_1","first-page":"5615","article-title":"COMETE Network. 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