{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T08:53:55Z","timestamp":1789894435344,"version":"4.0.1"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,2,18]],"date-time":"2016-02-18T00:00:00Z","timestamp":1455753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Glucocorticoid substitution is essential in patients with chronic primary adrenocortical insufficiency (Addison's disease) and both over\u2010treatment and inadequate dosage have deleterious effects. Individual sensitivity to glucocorticoids is partly genetically determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Context<\/jats:title><jats:p>To test the hypothesis whether the well\u2010characterized SNPs of the <jats:italic>GR<\/jats:italic> and <jats:italic>HSD11B1<\/jats:italic> genes may modulate the individual sensitivity to exogenous glucocorticoids and may influence clinical and\/or laboratory parameters and the glucocorticoid substitution dosage in patients with Addison's disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>68 patients with primary adrenocortical insufficiency were involved. Clinical and laboratory data, as well as the dosage of the hormone replacement therapy were collected. Peripheral blood DNA was isolated, and the <jats:italic>GR<\/jats:italic> and <jats:italic>HSD11B1<\/jats:italic> SNPs were examined using allele\u2010specific PCR or Taqman assay on Real Time PCR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The allele frequency of the <jats:italic>GR<\/jats:italic> N363S polymorphism was higher in patients compared to the control group and the disease appeared significantly earlier in patients harbouring the <jats:italic>GR<\/jats:italic> A3669G compared to noncarriers. These patients had higher ACTH level measured at the time of diagnosis. Homozygous <jats:italic>BclI<\/jats:italic> carriers had higher body mass index (BMI) and lower total hydrocortisone equivalent supplementation dose needed than heterozygous or noncarriers. The BMI and weight gain during hormone replacement therapy were also higher in carriers of the <jats:italic>HSD11B1<\/jats:italic> rs4844880 treated with glucocorticoids other than dexamethasone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The BclI polymorphism of the <jats:italic>GR<\/jats:italic> gene and the rs4844880 of the <jats:italic>HSD11B1<\/jats:italic> gene may contribute to weight gain and may affect the individual need of glucocorticoid substitution dose in these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13022","type":"journal-article","created":{"date-parts":[[2016,1,22]],"date-time":"2016-01-22T14:04:37Z","timestamp":1453471477000},"page":"180-188","source":"Crossref","is-referenced-by-count":15,"title":["Polymorphisms of the <i>GR<\/i> and <i>HSD11B1<\/i> genes influence body mass index and weight gain during hormone replacement treatment in patients with Addison's disease"],"prefix":"10.1111","volume":"85","author":[{"given":"\u00c1gnes","family":"Moln\u00e1r","sequence":"first","affiliation":[{"name":"2nd Department of Medicine Semmelweis University Budapest Hungary"},{"name":"Lend\u00fclet\u201d Hereditary Endocrine Tumours Research Group Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annam\u00e1ria","family":"K\u00f6vesdi","sequence":"additional","affiliation":[{"name":"2nd Department of Medicine Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolette","family":"Sz\u00fccs","sequence":"additional","affiliation":[{"name":"2nd Department of Medicine Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikl\u00f3s","family":"T\u00f3th","sequence":"additional","affiliation":[{"name":"2nd Department of Medicine Semmelweis University Budapest 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