{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T10:58:42Z","timestamp":1776855522218,"version":"3.51.2"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,2,25]],"date-time":"2016-02-25T00:00:00Z","timestamp":1456358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2016,6]]},"abstract":"Summary<\/jats:title>Objective<\/jats:title>Serum amino\u2010terminal propeptide of C\u2010type natriuretic peptide (NT<\/jats:styled-content>\u2010proCNP<\/jats:styled-content>) levels have been proposed as a biomarker of linear growth in healthy children. The usefulness of NT<\/jats:styled-content>\u2010proCNP<\/jats:styled-content> in patients with achondroplasia (ACH<\/jats:styled-content>)\/hypochondroplasia (HCH<\/jats:styled-content>) remains to be elucidated. The objective was to study whether serum NT<\/jats:styled-content>\u2010proCNP<\/jats:styled-content> level is a good biomarker for growth in ACH<\/jats:styled-content>\/HCH<\/jats:styled-content> and other patients of short stature.<\/jats:p><\/jats:sec>Design<\/jats:title>This was a longitudinal cohort study.<\/jats:p><\/jats:sec>Patients<\/jats:title>Sixteen children with ACH<\/jats:styled-content> (aged 0\u00b74\u20134\u00b73 years), six children with HCH<\/jats:styled-content> (2\u00b77\u20136\u00b73 years), 23 children with idiopathic short stature (ISS<\/jats:styled-content>) (2\u00b72\u20139\u00b70 years), eight short children with GH<\/jats:styled-content> deficiency (GHD<\/jats:styled-content>) (2\u00b79\u20136\u00b78 years) and five short children born small for gestational age (SGA<\/jats:styled-content>) (2\u00b70\u20136\u00b76 years). Patients with ACH<\/jats:styled-content>\/HCH<\/jats:styled-content> received GH<\/jats:styled-content> treatment for 1 year.<\/jats:p><\/jats:sec>Measurements<\/jats:title>Serum NT<\/jats:styled-content>\u2010proCNP<\/jats:styled-content> levels and height were measured.<\/jats:p><\/jats:sec>Results<\/jats:title>NT<\/jats:styled-content>\u2010proCNP<\/jats:styled-content> levels positively correlated with height velocity in these short children (P<\/jats:italic> < 0\u00b705, r<\/jats:italic> = 0\u00b727). NT<\/jats:styled-content>\u2010proCNP<\/jats:styled-content> levels inversely correlated with age in children with ISS<\/jats:styled-content> alone (P<\/jats:italic> < 0\u00b701, r<\/jats:italic> = \u22120\u00b755). Serum NT<\/jats:styled-content>\u2010proCNP<\/jats:styled-content> levels in patients with ACH<\/jats:styled-content>\/HCH<\/jats:styled-content> were increased 3 months following the initiation of GH<\/jats:styled-content> treatment (P<\/jats:italic> < 0\u00b705). Height SDS<\/jats:styled-content> gain during GH<\/jats:styled-content> treatment for 1 year was positively correlated with the changes in NT<\/jats:styled-content>\u2010proCNP<\/jats:styled-content> levels after the initiation of GH<\/jats:styled-content> (P<\/jats:italic> < 0\u00b701, r<\/jats:italic> = 0\u00b772).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Serum NT<\/jats:styled-content>\u2010proCNP<\/jats:styled-content> levels may be a good biomarker to indicate the effect of GH<\/jats:styled-content> treatment on growth in patients with ACH<\/jats:styled-content>\/HCH<\/jats:styled-content> at least in the first year and height velocity in short stature patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13025","type":"journal-article","created":{"date-parts":[[2016,1,27]],"date-time":"2016-01-27T06:58:45Z","timestamp":1453877925000},"page":"845-850","source":"Crossref","is-referenced-by-count":5,"title":["Serum NT<\/scp>\u2010proCNP<\/scp> levels increased after initiation of 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