{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T12:53:53Z","timestamp":1771505633575,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,3,22]],"date-time":"2016-03-22T00:00:00Z","timestamp":1458604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Context<\/jats:title><jats:p>Existing data regarding the association between growth hormone deficiency (<jats:styled-content style=\"fixed-case\">GHD<\/jats:styled-content>) and liver fat content are conflicting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed (i) to assess intrahepatocellular lipid (<jats:styled-content style=\"fixed-case\">IHCL<\/jats:styled-content>) content in hypopituitary adults with <jats:styled-content style=\"fixed-case\">GHD<\/jats:styled-content> compared to matched controls and (ii) to evaluate the effect of growth hormone (<jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content>) replacement on <jats:styled-content style=\"fixed-case\">IHCL<\/jats:styled-content> content.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Cross\u2010sectional comparison and controlled intervention study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<jats:italic><jats:bold>,<\/jats:bold><\/jats:italic> Participants<\/jats:title><jats:p>Cross\u2010sectional comparison: Twenty\u2010two hypopituitary adults with <jats:styled-content style=\"fixed-case\">GHD<\/jats:styled-content> and 44 healthy controls matched for age, <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>, gender and ethnicity. Intervention study: nine <jats:styled-content style=\"fixed-case\">GHD<\/jats:styled-content> patients starting <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content> replacement (<jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content> Rx group) and nine <jats:styled-content style=\"fixed-case\">GHD<\/jats:styled-content> patients not starting replacement therapy (non\u2010<jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content> Rx group).<\/jats:p><\/jats:sec><jats:sec><jats:title>Intervention<\/jats:title><jats:p>Intervention study: <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content> replacement for 6 months in the <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content> Rx group, dosage was titrated to achieve normal <jats:styled-content style=\"fixed-case\">IGF<\/jats:styled-content>\u20101 levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HCL<\/jats:styled-content> content determined by proton magnetic resonance spectroscopy (<jats:sup>1<\/jats:sup>H <jats:styled-content style=\"fixed-case\">MRS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cross\u2010sectional Comparison: There was no difference in <jats:styled-content style=\"fixed-case\">IHCL<\/jats:styled-content> content between <jats:styled-content style=\"fixed-case\">GHD<\/jats:styled-content> patients and healthy controls (1\u00b789% (0\u00b730, 4\u00b703) <jats:italic>vs<\/jats:italic> 1\u00b714% (0\u00b722, 2\u00b732); <jats:italic>P<\/jats:italic> = 0\u00b72), and the prevalence of patients with hepatic steatosis (<jats:styled-content style=\"fixed-case\">IHCL<\/jats:styled-content> of \u2265 5\u00b756%) was similar in the two groups (22\u00b77% vs 15\u00b79%; chi\u2010square probability = 0\u00b74). Intervention study: The change in <jats:styled-content style=\"fixed-case\">IHCL<\/jats:styled-content> content over 6 months did not differ between the <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content> Rx group and the non\u2010<jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content> Rx group (\u22120\u00b763 \u00b1 4\u00b753% vs + 0\u00b711 \u00b1 1\u00b746%; <jats:italic>P<\/jats:italic> = 0\u00b76).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In our study, liver fat content and the prevalence of hepatic steatosis did not differ between hypopituitary adults with <jats:styled-content style=\"fixed-case\">GHD<\/jats:styled-content> and matched controls. In <jats:styled-content style=\"fixed-case\">GHD<\/jats:styled-content> patients, <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content> replacement had no effect on liver fat content.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13042","type":"journal-article","created":{"date-parts":[[2016,2,20]],"date-time":"2016-02-20T20:58:01Z","timestamp":1456001881000},"page":"76-84","source":"Crossref","is-referenced-by-count":25,"title":["Liver fat in adults with <scp>GH<\/scp> deficiency: comparison to matched controls and the effect of <scp>GH<\/scp> replacement"],"prefix":"10.1111","volume":"85","author":[{"given":"Fabian","family":"Meienberg","sequence":"first","affiliation":[{"name":"Department of Endocrinology Diabetes and Metabolism University Hospital Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Yee","sequence":"additional","affiliation":[{"name":"Metabolic Medicine Unit St Mary's Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Desmond","family":"Johnston","sequence":"additional","affiliation":[{"name":"Department of Medicine Faculty of Medicine Imperial College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Cox","sequence":"additional","affiliation":[{"name":"Metabolic Medicine Unit St Mary's Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Robinson","sequence":"additional","affiliation":[{"name":"Metabolic Medicine Unit St Mary's Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jimmy D.","family":"Bell","sequence":"additional","affiliation":[{"name":"Department of Life Sciences Faculty of Science and Technology University of Westminster London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. Louise","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Life Sciences Faculty of Science and Technology University of Westminster London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon D.","family":"Taylor\u2010Robinson","sequence":"additional","affiliation":[{"name":"Hepatology Department of Medicine Faculty of Medicine Imperial College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Godsland","sequence":"additional","affiliation":[{"name":"Division of Diabetes Endocrinology and Metabolism Department of Medicine Faculty of Medicine Imperial College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.75.3.833"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1993.tb00974.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0179"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-2371"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-11-0558"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66378-7"},{"issue":"1","key":"e_1_2_6_8_1","first-page":"S17","article-title":"Pathophysiology of nonalcoholic steatohepatitis","volume":"40","author":"McCullough A.J.","year":"2006","journal-title":"Journal of Clinical Gastroenterology"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25762"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(14)70032-4"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.33573"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1265217"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.6.914"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e3181a84bde"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000074248"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.76.6.537"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.12.024"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-12-0252"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-12-0002"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-2394"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2008-0027"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2011.142"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.87.6.2068"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.036566"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.85.5.1778"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.316.7139.1236"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20466"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23129"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2000.00862.x"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.2000.00695.x"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1243605"},{"key":"e_1_2_6_32_1","first-page":"37","article-title":"Long\u2010term effects of growth hormone therapy on intermediary metabolism and insulin sensitivity in hypopituitary adults","volume":"22","author":"Johnston D.G.","year":"1999","journal-title":"Journal of Endocrinological Investigation"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-12-1088"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-014-3193-0"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2007.05.008"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.2337\/db10-1221"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.4.1247"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcen.13042","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.13042","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T12:14:58Z","timestamp":1695471298000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.13042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,22]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1111\/cen.13042"],"URL":"https:\/\/doi.org\/10.1111\/cen.13042","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,22]]}}}