{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T23:16:30Z","timestamp":1775862990857,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,3,10]],"date-time":"2016-03-10T00:00:00Z","timestamp":1457568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The effects of thiazide medication in patients with primary hyperparathyroidism (<jats:styled-content style=\"fixed-case\">PHPT<\/jats:styled-content>) have so far not been elucidated. The aim of this study was to analyse the extent to which the administration of thiazides may influence biochemical parameters and therefore the diagnosis of <jats:styled-content style=\"fixed-case\">PHPT<\/jats:styled-content> in a large cohort of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and patients<\/jats:title><jats:p>The biochemical parameters of 1066 patients with <jats:styled-content style=\"fixed-case\">PHPT<\/jats:styled-content> were analysed, and drug history was documented. Calcium (Ca)\/creatinine clearance ratio (<jats:styled-content style=\"fixed-case\">CCCR<\/jats:styled-content>) was calculated. The results of patients given thiazides (<jats:italic>n<\/jats:italic> = 170) and those not given thiazides (<jats:italic>n<\/jats:italic> = 896) were analysed and compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Twenty\u2010four\u2010hour urinary calcium excretion (24hU), albumin\u2010corrected serum calcium, <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>, creatinine, 1,25<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>\u2010 and 25<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>\u2010vitamin D were measured, and <jats:styled-content style=\"fixed-case\">CCCR<\/jats:styled-content> was calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>24h<jats:styled-content style=\"fixed-case\">U<jats:sub>C<\/jats:sub><\/jats:styled-content><jats:sub>a<\/jats:sub> and <jats:styled-content style=\"fixed-case\">CCCR<\/jats:styled-content> were significantly lower in patients on thiazides (<jats:italic>P<\/jats:italic> = 0\u00b702 and <jats:italic>P<\/jats:italic> = 0\u00b70068, resp.), and serum creatinine was significantly higher in those subjects (<jats:italic>P<\/jats:italic> &lt; 0\u00b70001). Serum Ca levels only proved different in an analysis of covariance among patients younger than 60 years (<jats:italic>P<\/jats:italic> = 0\u00b7003). Nevertheless, <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> was not different in both groups (<jats:italic>P<\/jats:italic> = 0\u00b7917).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>According to recently published guidelines, 24h<jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content>a measurement is necessary to give indication for surgery in asymptomatic patients and to distinguish between <jats:styled-content style=\"fixed-case\">PHPT<\/jats:styled-content> and familial hypocalciuric hypercalcaemia [<jats:styled-content style=\"fixed-case\">FHH<\/jats:styled-content>]. Thiazides significantly decrease 24h<jats:styled-content style=\"fixed-case\">U<jats:sub>C<\/jats:sub><\/jats:styled-content><jats:sub>a<\/jats:sub>, yet neither increase serum Ca nor influence <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> levels in patients with <jats:styled-content style=\"fixed-case\">PHPT<\/jats:styled-content>. However, discontinuing thiazides is crucial for a correct <jats:styled-content style=\"fixed-case\">CCCR<\/jats:styled-content> calculation to pre\u2010operatively rule out <jats:styled-content style=\"fixed-case\">FHH<\/jats:styled-content>. As a consequence, the withdrawal of thiazide medication must be recommended for the diagnosis of <jats:styled-content style=\"fixed-case\">PHPT<\/jats:styled-content> prior to surgery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13046","type":"journal-article","created":{"date-parts":[[2016,2,27]],"date-time":"2016-02-27T15:05:17Z","timestamp":1456585517000},"page":"196-201","source":"Crossref","is-referenced-by-count":22,"title":["The influence of thiazide intake on calcium and parathyroid hormone levels in patients with primary hyperparathyroidism"],"prefix":"10.1111","volume":"85","author":[{"given":"Philipp","family":"Riss","sequence":"first","affiliation":[{"name":"Section of Endocrine Surgery Division of General Surgery Department of Surgery Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Kammer","sequence":"additional","affiliation":[{"name":"Section for Clinical Biometrics Center for Medical Statistics, Informatics and Intelligent Systems (CeMSIIS) Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Selberherr","sequence":"additional","affiliation":[{"name":"Section of Endocrine Surgery Division of General Surgery Department of Surgery Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Bichler","sequence":"additional","affiliation":[{"name":"Section of Endocrine Surgery Division of General Surgery Department of Surgery Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reto","family":"Kaderli","sequence":"additional","affiliation":[{"name":"Section of Endocrine Surgery Division of General Surgery Department of Surgery Medical University of Vienna Vienna 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