{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T08:30:20Z","timestamp":1769070620962,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,3,21]],"date-time":"2016-03-21T00:00:00Z","timestamp":1458518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Previous studies have reported recovery of secondary adrenal insufficiency (<jats:styled-content style=\"fixed-case\">SAI<\/jats:styled-content>) in patients with pituitary disorders, generally immediately after pituitary surgery; however, data regarding recovery of long\u2010term <jats:styled-content style=\"fixed-case\">SAI<\/jats:styled-content> are lacking. We conducted a study to assess the longer term recovery rate of <jats:styled-content style=\"fixed-case\">SAI<\/jats:styled-content> in patients with pituitary disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We identified all <jats:styled-content style=\"fixed-case\">SAI<\/jats:styled-content> patients in the Halifax Neuropituitary Database from 1 November 2005 to 30 September 2014, who had required glucocorticoid therapy for \u22653 months, and had a minimum follow\u2010up of 6 months. Patients with <jats:styled-content style=\"fixed-case\">ACTH<\/jats:styled-content>\u2010secreting adenomas, those receiving glucocorticoids only in the routine peri\u2010operative period for pituitary surgery and those on glucocorticoids for nonpituitary conditions were excluded. <jats:styled-content style=\"fixed-case\">SAI<\/jats:styled-content> was defined as either basal serum cortisol &lt; 130 n<jats:sc>m<\/jats:sc> and\/or a subnormal cortisol response to <jats:styled-content style=\"fixed-case\">ACTH<\/jats:styled-content>\u2010(1\u201324) stimulation test or insulin tolerance test response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010one patients fulfilled the criteria. Nine (17\u00b76%) patients had complete recovery of <jats:styled-content style=\"fixed-case\">SAI<\/jats:styled-content> over a median of 20 months (range: 8\u201351) after initiating glucocorticoid replacement. Patients with smaller tumour size had increased likelihood of hypothalamic\u2013pituitary\u2013adrenal (<jats:styled-content style=\"fixed-case\">HPA<\/jats:styled-content>) axis recovery, whereas those with secondary hypogonadism or growth hormone deficiency were less likely to recover. Those with initial cortisol &gt;175 n<jats:sc>m<\/jats:sc> had an almost one in two chance of recovery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Results from our study show that approximately one in six patients with <jats:styled-content style=\"fixed-case\">SAI<\/jats:styled-content> recover adrenal function, even up to 5 years after diagnosis. We recommend that patients with <jats:styled-content style=\"fixed-case\">SAI<\/jats:styled-content> undergo regular testing to assess recovery in order to prevent unnecessary glucocorticoid therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13048","type":"journal-article","created":{"date-parts":[[2016,2,29]],"date-time":"2016-02-29T15:37:26Z","timestamp":1456760246000},"page":"216-222","source":"Crossref","is-referenced-by-count":22,"title":["Recovery of adrenal function after chronic secondary adrenal insufficiency in patients with hypopituitarism"],"prefix":"10.1111","volume":"85","author":[{"given":"V.","family":"Munro","sequence":"first","affiliation":[{"name":"Division of Endocrinology Department of Medicine Dalhousie University Halifax NS Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Tugwell","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Department of Medicine Dalhousie University Halifax NS 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