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Published large series of <jats:styled-content style=\"fixed-case\">PS<\/jats:styled-content> lesions demonstrate neoplastic conditions are most frequent, followed by inflammatory, infectious and congenital diseases. Inflammatory pathologies however, account for the majority of <jats:styled-content style=\"fixed-case\">PS<\/jats:styled-content> lesions in published small case series and case reports. Physicians must be familiar with the major differential diagnoses and necessary investigations. A comprehensive history and thorough clinical examination is critical. Although magnetic resonance imaging of the <jats:styled-content style=\"fixed-case\">PS<\/jats:styled-content> in disease is nonspecific, associated intracranial features may narrow the differential diagnosis. Initial investigations include basic pathology and computer tomography imaging of the neck, chest, abdomen and pelvis. Further investigations should be guided by the clinical context. <jats:styled-content style=\"fixed-case\">PS<\/jats:styled-content> biopsy should be considered when a diagnosis is regarded essential in centres where an experienced neurosurgeon is available. Treatment is dependent on the underlying disease process and may necessitate pituitary hormone replacement.<\/jats:p>","DOI":"10.1111\/cen.13058","type":"journal-article","created":{"date-parts":[[2016,3,7]],"date-time":"2016-03-07T14:24:41Z","timestamp":1457360681000},"page":"507-521","source":"Crossref","is-referenced-by-count":52,"title":["Pituitary stalk lesions: systematic review and clinical guidance"],"prefix":"10.1111","volume":"85","author":[{"given":"Sarah","family":"Catford","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Diabetes Western Health Melbourne Vic. 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