{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:36:43Z","timestamp":1792226203578,"version":"4.4.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,4,15]],"date-time":"2016-04-15T00:00:00Z","timestamp":1460678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Pharmacological treatment is mandatory in patients with hormonally functional phaeochromocytoma and paraganglioma (<jats:styled-content style=\"fixed-case\">PHAEO<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">PGL<\/jats:styled-content>). We evaluated if patients initially diagnosed with hormonally functional <jats:styled-content style=\"fixed-case\">PHAEO<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">PGL<\/jats:styled-content> by various medical subspecialties received proper adrenoceptor blockade, and analysed factors predicting the prescription of adequate treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a retrospective cohort study, we reviewed data from patients initially diagnosed with hormonally functional <jats:styled-content style=\"fixed-case\">PHAEO<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">PGL<\/jats:styled-content> outside the National Institutes of Health and Cedars\u2010Sinai Medical Center, who were referred to these institutions between January 2001 and April 2015. Logistic regression was used to assess factors associated with proper adrenoceptor blockade.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 381 patients were included. Adequate pharmacological treatment was prescribed to 69\u00b73%, of which 93\u00b71% received \u03b1\u2010adrenoceptor blockers. Regarding patients who were inappropriately treated, 53% did not receive any medication. Independent predictors of the prescription of a proper blockade were the diagnosis by endocrinologists [odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) 4\u00b714; 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>), 2\u00b751\u20136\u00b785; <jats:italic>P<\/jats:italic> &lt; 0\u00b7001], the presence of high blood pressure (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 5\u00b794; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 3\u00b711\u201311\u00b733; <jats:italic>P<\/jats:italic> &lt; 0\u00b7001) and the evidence of metastasis (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 5\u00b796; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1\u00b793\u201318\u00b746; <jats:italic>P<\/jats:italic> = 0\u00b7002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although most patients received adequate pharmacological treatment, almost one\u2010third were either not treated or received inappropriate medications. The diagnosis by endocrinologists, the presence of high blood pressure and the evidence of metastatic disease were identified as independent predictors of a proper blockade. These results highlight the need to educate physicians about the importance of starting adequate adrenoceptor blockade in all patients with hormonally functional <jats:styled-content style=\"fixed-case\">PHAEO<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">PGL<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13066","type":"journal-article","created":{"date-parts":[[2016,3,22]],"date-time":"2016-03-22T01:35:52Z","timestamp":1458610552000},"page":"62-69","source":"Crossref","is-referenced-by-count":16,"title":["Are patients with hormonally functional phaeochromocytoma and paraganglioma initially receiving a proper adrenoceptor blockade? A retrospective cohort study"],"prefix":"10.1111","volume":"85","author":[{"given":"Henrique Vara","family":"Luiz","sequence":"first","affiliation":[{"name":"Program in Reproductive and Adult Endocrinology Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Bethesda MD USA"},{"name":"Department of Endocrinology and Diabetology Hospital Garcia de Orta Almada Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Jane","family":"Tanchee","sequence":"additional","affiliation":[{"name":"Program in Reproductive and Adult Endocrinology Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Bethesda MD USA"},{"name":"Section of Endocrinology and Metabolism University of Santo Tomas Hospital Espa\u00f1a Manila Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria G.","family":"Pavlatou","sequence":"additional","affiliation":[{"name":"Clinical Neuroendocrinology Branch National Institute of Mental Health National Institutes of Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Run","family":"Yu","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Carcinoid and Neuroendocrine Tumour Center Cedars\u2010Sinai Medical Center Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Nambuba","sequence":"additional","affiliation":[{"name":"Program in Reproductive and Adult Endocrinology Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Wolf","sequence":"additional","affiliation":[{"name":"Program in Reproductive and Adult Endocrinology Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Prodanov","sequence":"additional","affiliation":[{"name":"Program in Reproductive and Adult Endocrinology Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Wesley","sequence":"additional","affiliation":[{"name":"Warren Grant Magnuson Clinical Center National Institutes of Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Adams","sequence":"additional","affiliation":[{"name":"Program in Reproductive and Adult Endocrinology Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tito","family":"Fojo","sequence":"additional","affiliation":[{"name":"Center for Cancer Research National Cancer Institute National Institutes of Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karel","family":"Pacak","sequence":"additional","affiliation":[{"name":"Program in Reproductive and Adult Endocrinology Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e3181ebb4f0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/CRD.0b013e3181a6de40"},{"key":"e_1_2_8_4_1","first-page":"137","volume-title":"World Health Organization Classification of Tumours. 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