{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T02:54:51Z","timestamp":1789786491073,"version":"4.0.1"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,5,11]],"date-time":"2016-05-11T00:00:00Z","timestamp":1462924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2016,10]]},"abstract":"Summary<\/jats:title>\n \n Objectives<\/jats:title>\n \n Estimates of high blood pressure (\n BP<\/jats:styled-content>\n ) incidence in children with congenital adrenal hyperplasia (\n CAH<\/jats:styled-content>\n ) vary widely; risk factors are poorly understood. We estimated incidence of hypertension by\n CAH<\/jats:styled-content>\n subtype and sex, and assessed its association with body mass index, hydrocortisone and fludrocortisone.\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Longitudinal.<\/jats:p>\n <\/jats:sec>\n \n Patients<\/jats:title>\n \n Chart review of 180 paediatric\n CAH<\/jats:styled-content>\n patients (120 salt wasting; 60 simple virilizing; 93 females) seen from 1970 to 2013.\n <\/jats:p>\n <\/jats:sec>\n \n Measurements<\/jats:title>\n \n High\n BP<\/jats:styled-content>\n was diagnosed by diastolic or systolic blood pressure measurement \u226595th percentile for age, sex and height; hypertension was diagnosed with high\n BP<\/jats:styled-content>\n on at least three clinic visits.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Children with classic\n CAH<\/jats:styled-content>\n who received fludrocortisone had a significantly higher rate of hypertension (55%\n vs<\/jats:italic>\n 31%) than those who did not. Hypertension incidence was higher in salt\u2010wasting\n CAH<\/jats:styled-content>\n (58%) than in simple\u2010virilizing\n CAH<\/jats:styled-content>\n (35%). Hypertension first occurred before age 5 years in 91% of salt\u2010wasting males and 50% of cases in salt\u2010wasting females; most simple\u2010virilizing cases occurred during ages 10\u201318 years. Rates of hypertension were higher in children who had three or more measurements with 17\u2010\n OHP<\/jats:styled-content>\n < 400 ng\/dl (12\u00b712 nmol\/l), and this difference was significant in salt\u2010wasting males. Children on fludrocortisone who had three or more readings of 17\u2010\n OHP<\/jats:styled-content>\n < 400 ng\/dl (12\u00b712 nmol\/l) had a significantly higher rate of hypertension than those who did not. Hydrocortisone dose was not associated with hypertension.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Children with\n CAH<\/jats:styled-content>\n are at higher risk for hypertension than the general paediatric population, and incidence differs by sex and\n CAH<\/jats:styled-content>\n subtype. Hypertension was higher in children on fludrocortisone and who were oversuppressed.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/cen.13086","type":"journal-article","created":{"date-parts":[[2016,4,22]],"date-time":"2016-04-22T19:11:54Z","timestamp":1461352314000},"page":"528-534","source":"Crossref","is-referenced-by-count":45,"title":["Hypertension in children with congenital adrenal hyperplasia"],"prefix":"10.1111","volume":"85","author":[{"given":"Nadia","family":"Maccabee\u2010Ryaboy","sequence":"first","affiliation":[{"name":"University of Minnesota Masonic Children's Hospital Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Thomas","sequence":"additional","affiliation":[{"name":"Division of Biostatistics School of Public Health University of Minnesota Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Kyllo","sequence":"additional","affiliation":[{"name":"Children's 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