{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T17:16:02Z","timestamp":1768583762918,"version":"3.49.0"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,6,13]],"date-time":"2016-06-13T00:00:00Z","timestamp":1465776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Zon-MW TOP","award":["91212044"],"award-info":[{"award-number":["91212044"]}]},{"name":"DFG Grants Priority Programme"},{"name":"Erasmus MC MRACE","award":["1629"],"award-info":[{"award-number":["1629"]}]},{"name":"Thyroid Trans Act","award":["KO-922\/17-1\/2"],"award-info":[{"award-number":["KO-922\/17-1\/2"]}]},{"name":"DFG Graduate Programme","award":["GRK 1208\/2 TP 3"],"award-info":[{"award-number":["GRK 1208\/2 TP 3"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Levothyroxine (<jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>4) is the standard of care in patients with hypothyroidism. Despite this replacement therapy, quality of life (QoL) remains impaired in a substantial amount of patients. The reasons for this are still a matter of debate. Suggested causes include lack of endogenous T3 secretion by the thyroid, changes in other thyroid hormone metabolites and interference by autoimmune processes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the association between thyroid function tests (<jats:styled-content style=\"fixed-case\">TFT<\/jats:styled-content>s) and QoL in patients with a history of differentiated thyroid cancer on <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>4 monotherapy. These patients lack endogenous thyroidal T3 secretion in the absence of autoimmune disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This is a cross\u2010sectional study in 143 patients (69\u00b72% female). Initial therapy consisted of total thyroidectomy followed by radioiodine ablation minimally one year before inclusion. We assessed health\u2010related QoL (<jats:styled-content style=\"fixed-case\">RAND<\/jats:styled-content>\u201036), thyroid\u2010specific QoL (Thy<jats:styled-content style=\"fixed-case\">PRO<\/jats:styled-content>) and fatigue with the Multidimensional Fatigue Inventory. Extensive <jats:styled-content style=\"fixed-case\">TFT<\/jats:styled-content>s were assessed, including 3,5\u2010diiodo\u2010L\u2010thyronine (3,5\u2010T2).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean age was 50\u00b72 years and mean time since diagnosis was 8\u00b74 years. Median <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content> was 0\u00b7042 mU\/l, total T4 145\u00b70 nmol\/l, free T4 25\u00b76 pmol\/l, total T3 1\u00b793 nmol\/l, reverse T3 0\u00b753 nmol\/l and 3,5\u2010T2 0\u00b786 nmol\/l. Multiple linear regression analyses did not show any association between QoL and the different <jats:styled-content style=\"fixed-case\">TFT<\/jats:styled-content>s, including T4\/T3 and 3,5\u2010T2\/T3 ratios reflecting peripheral metabolism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We did not find any association between <jats:styled-content style=\"fixed-case\">TFT<\/jats:styled-content>s and QoL in athyreotic patients on <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>4 monotherapy. Our data do not provide evidence that a slight increase in dose improves fatigue or well\u2010being in hypothyroid patients on <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>4 therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13101","type":"journal-article","created":{"date-parts":[[2016,5,13]],"date-time":"2016-05-13T16:15:11Z","timestamp":1463156111000},"page":"781-788","source":"Crossref","is-referenced-by-count":42,"title":["Thyroid hormone and its metabolites in relation to quality of life in patients treated for differentiated thyroid cancer"],"prefix":"10.1111","volume":"85","author":[{"given":"E.T.","family":"Massolt","sequence":"first","affiliation":[{"name":"Division of Endocrinology Department of Internal Medicine Erasmus MC Rotterdam the Netherlands"},{"name":"Rotterdam Thyroid Center Department of Internal Medicine Erasmus MC Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"van der Windt","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Department of Internal Medicine Erasmus MC Rotterdam the Netherlands"},{"name":"Rotterdam Thyroid Center Department of Internal Medicine Erasmus MC Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.I.M.","family":"Korevaar","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Department of Internal Medicine Erasmus MC Rotterdam the Netherlands"},{"name":"Rotterdam Thyroid Center Department of Internal Medicine Erasmus MC Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.L.R.","family":"Kam","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Erasmus MC Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.W.","family":"Burger","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology Department of Surgery Erasmus MC Cancer Institute Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.J.H.","family":"Franssen","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology Department of Surgery Erasmus MC Cancer Institute Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Lehmphul","sequence":"additional","affiliation":[{"name":"Institute of Experimental Endocrinology Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"K\u00f6hrle","sequence":"additional","affiliation":[{"name":"Institute of Experimental Endocrinology Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.E.","family":"Visser","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Department of Internal Medicine Erasmus MC Rotterdam the Netherlands"},{"name":"Rotterdam Thyroid Center Department of Internal Medicine Erasmus MC Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.P.","family":"Peeters","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Department of Internal Medicine Erasmus MC Rotterdam the Netherlands"},{"name":"Rotterdam Thyroid Center Department of Internal Medicine Erasmus MC Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/105072502761016458"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2002.01654.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.02025"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2008.03521.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2006.0252"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-15-0395"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2009.06.030"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-4-25"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000342623"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-1203"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2012.741326"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2002.01682.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2006.02478.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106304"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-11-1029"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.7.769"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.137.6.8641203"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-09-0542"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199902113400603"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNM.0b013e32832c79e0"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-0448"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-0099"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2013.0688"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0052328"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0116498"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-014-0798-1"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3999(94)00125-O"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1207\/s15327558ijbm0302_2"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853890109002089"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2014.0262"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022552"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-3686"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2013.0017"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2007.0248"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-13-0502"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2014-1604"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0140837"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2015.30.3.343"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2011.0054"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcen.13101","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.13101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T15:48:14Z","timestamp":1695484094000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.13101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,13]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1111\/cen.13101"],"URL":"https:\/\/doi.org\/10.1111\/cen.13101","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,13]]}}}