{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T18:46:45Z","timestamp":1759776405237},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,7,21]],"date-time":"2016-07-21T00:00:00Z","timestamp":1469059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Studies of thyroid cancer related to the Chernobyl accident have focused on children as they are the most vulnerable group with the highest risk of developing radiation\u2010associated cancer. In contrast, our research aimed to look at the clinical and pathological features of patients with post\u2010Chernobyl papillary thyroid carcinoma that were 2 years old or less at the time of the Chernobyl accident.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>The study subjects were patients (<jats:italic>n<\/jats:italic> = 359) aged 0 to 2 at the time of the Chernobyl accident and aged \u226519 years at presentation\/surgery who were treated in Belarus for papillary thyroid carcinoma during the period 2003\u20132013.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In conventional or oncocytic variant of papillary thyroid carcinoma, the prevalence of extra\u2010thyroidal extension, nodal disease, infiltrative growth or lymphatic vessel invasion was above 50%. These features were less pronounced when compared to tall cell or diffuse sclerosing variants of papillary thyroid carcinoma. The highest frequency of central lymph node metastases was found in patients aged 1\u20132 years at exposure (<jats:italic>P<\/jats:italic> = 0\u00b7004). Subjects exposed in utero were characterized by absent\/insignificant lymphocytic infiltration around the carcinoma (<jats:italic>P<\/jats:italic> = 0\u00b7025), predominance of conventional papillary architecture and an association with lymphocytic thyroiditis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A number of features were associated with this group of patients that were very young at the time of radiation exposure. In addition, the incidence and basic characteristics of adult papillary thyroid carcinoma varied depending on the types of exposure conditions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13137","type":"journal-article","created":{"date-parts":[[2016,6,17]],"date-time":"2016-06-17T14:53:21Z","timestamp":1466175201000},"page":"971-978","source":"Crossref","is-referenced-by-count":16,"title":["Characteristics of young adults of Belarus with post\u2010Chernobyl papillary thyroid carcinoma: a long\u2010term follow\u2010up of patients with early exposure to radiation at the 30th anniversary of the accident"],"prefix":"10.1111","volume":"85","author":[{"given":"Mikhail","family":"Fridman","sequence":"first","affiliation":[{"name":"Republican Centre for Thyroid Tumors Minsk Belarus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfred King\u2010yin","family":"Lam","sequence":"additional","affiliation":[{"name":"School of Medicine and Menzies Health Institute Queensland Griffith University Gold Coast QLD Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"Krasko","sequence":"additional","affiliation":[{"name":"United Institute of Informatics Problems, National Academy of Sciences of Belarus Minsk Belarus"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-006-0001-5"},{"key":"e_1_2_9_3_1","unstructured":"United Nations(2011).Sources and effects of ionizing radiation. Report to the General Assembly vol. II Scienti?c Annexes C D and E UNSCEAR 2008 Report.United Nations Vienna Austria."},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2009.349"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2011.01.502"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2011.01.510"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-3131"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2015.03.039"},{"key":"e_1_2_9_9_1","volume-title":"American Joint Committee on Cancer. Cancer Staging Manual","author":"Amin M.B.","year":"2017"},{"key":"e_1_2_9_10_1","first-page":"51","volume-title":"World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of Endocrine Organs","author":"DeLellis R.A.","year":"2004"},{"key":"e_1_2_9_11_1","volume-title":"R: A language and Environment for Statistical Computing","author":"R Core Team","year":"2015"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1385\/EP:16:4:323"},{"key":"e_1_2_9_13_1","first-page":"1","article-title":"Diffuse sclerosing variant of papillary carcinoma of the thyroid: a 35\u2010year comparative study at a single institution","volume":"13","author":"Lam A.K.","year":"2006","journal-title":"Annual of Surgical Oncology"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2014.12.001"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcen.13137","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcen.13137","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.13137","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T08:21:26Z","timestamp":1695543686000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.13137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,21]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1111\/cen.13137"],"URL":"https:\/\/doi.org\/10.1111\/cen.13137","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,21]]}}}