{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T04:11:48Z","timestamp":1780978308657,"version":"3.54.1"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,7,19]],"date-time":"2016-07-19T00:00:00Z","timestamp":1468886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Teriparatide, an anabolic agent used in the treatment of postmenopausal osteoporosis, can induce effects similar to primary hyperparathyroidism. Our objective was to evaluate the effects of teriparatide on endothelial functions, glucose metabolism and inflammation markers in patients diagnosed with postmenopausal osteoporosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design, patients and measurements<\/jats:title><jats:p>This was a single\u2010centre, single\u2010arm, 6\u2010month prospective study. Twenty\u2010three postmenopausal women over 65\u00a0years old with a lumbar spine or femoral neck T\u2010score of \u22124\u00b70 or lower and having at least two compression fractures in thoracic or lumbar spine were studied. Low\u2010dose intermittent teriparatide (20\u00a0\u03bcg\/day) was supplemented with calcium carbonate (1000\u00a0mg elemental calcium) and 880<jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>cholecalciferol for 6\u00a0months. The biochemical parameters for glucose metabolism, inflammation and atherosclerosis were determined. For the assessment of vascular endothelial function, carotid intima\u2010media thickness (<jats:styled-content style=\"fixed-case\">CIMT<\/jats:styled-content>), brachial artery intima\u2010media thickness (<jats:styled-content style=\"fixed-case\">BIMT<\/jats:styled-content>), per cent change in flow\u2010mediated dilation (<jats:styled-content style=\"fixed-case\">FMD<\/jats:styled-content>%) and nitroglycerine\u2010induced dilations (<jats:styled-content style=\"fixed-case\">NID<\/jats:styled-content>%) were measured on ultrasonography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The fasting plasma glucose, homoeostatic model assessment of insulin resistance, fibrinogen, homocysteine and high\u2010density lipoprotein cholesterol increased significantly with teriparatide treatment (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705 for all). Baseline<jats:styled-content style=\"fixed-case\">CIMT<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">BIMT<\/jats:styled-content>did not change significantly with 6 months of teriparatide treatment (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00\u00b705); however,<jats:styled-content style=\"fixed-case\">FMD<\/jats:styled-content>% and<jats:styled-content style=\"fixed-case\">NID<\/jats:styled-content>% showed significant decrease after treatment (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b701 for both).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intermittent teriparatide treatment may adversely affect some parameters of glucose metabolism, inflammation and endothelial function. On the basis of our findings, further large\u2010scale and controlled studies are needed to clarify the exact effect of teriparatide treatment on glucose metabolism, inflammation and endothelial function.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13139","type":"journal-article","created":{"date-parts":[[2016,6,20]],"date-time":"2016-06-20T07:46:46Z","timestamp":1466408806000},"page":"556-560","source":"Crossref","is-referenced-by-count":19,"title":["Effect of teriparatide treatment on endothelial function, glucose metabolism and inflammation markers in patients with postmenopausal osteoporosis"],"prefix":"10.1111","volume":"85","author":[{"given":"Ozgen","family":"Celer","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism Eskisehir Osmangazi University Eskisehir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aysen","family":"Akal\u0131n","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism 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