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Physical functional was assessed by the stair climb test, chair stand test, 7\u2010day pedometry and QoL by the <jats:styled-content style=\"fixed-case\">AGHDA<\/jats:styled-content> questionnaire. Lean body mass (<jats:styled-content style=\"fixed-case\">LBM<\/jats:styled-content>) was quantified by dual\u2010energy X\u2010ray absorptiometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content> replacement normalized <jats:styled-content style=\"fixed-case\">IGF<\/jats:styled-content>\u20101 levels during both study phases. During the 1\u2010month placebo\u2010controlled study, improvement in stair climb and chair stand performance was observed during <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content> and placebo treatment; however, there were no significant <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content> effects observed in any outcome measure compared to placebo. Six months of <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content> treatment significantly increased anaerobic power (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705), chair stand repetitions (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b70001), daily step count (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705) and QoL scores (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001) compared to baseline measurements. <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content> treatment did not significantly improve <jats:styled-content style=\"fixed-case\">VO<\/jats:styled-content><jats:sub>2<\/jats:sub>max. Improvement in anaerobic power independently predicted an improvement in energy and vitality domain of QoL (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b703).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content> replacement improves anaerobic capacity, physical function and QoL in a time\u2010dependent manner in adults with <jats:styled-content style=\"fixed-case\">GHD<\/jats:styled-content>. Improvement in the anaerobic but not aerobic energy system is likely to underlie the improvement in QoL in patients with <jats:styled-content style=\"fixed-case\">GHD<\/jats:styled-content> during <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content> replacement.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13147","type":"journal-article","created":{"date-parts":[[2016,6,27]],"date-time":"2016-06-27T08:12:42Z","timestamp":1467015162000},"page":"660-668","source":"Crossref","is-referenced-by-count":21,"title":["Growth hormone (<scp>GH<\/scp>) enhances anaerobic capacity: impact on physical function and quality of life in adults with <scp>GH<\/scp> deficiency"],"prefix":"10.1111","volume":"85","author":[{"given":"Viral","family":"Chikani","sequence":"first","affiliation":[{"name":"Department of Diabetes and Endocrinology Princess Alexandra Hospital Brisbane Qld Australia"},{"name":"School of Medicine University of Queensland Brisbane Qld Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ross C.","family":"Cuneo","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology Princess Alexandra Hospital Brisbane Qld Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid","family":"Hickman","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics Princess Alexandra Hospital Brisbane Qld Australia"},{"name":"Mater Research Institute University of Queensland Brisbane Qld Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken K.Y.","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology Princess Alexandra Hospital Brisbane Qld Australia"},{"name":"School of Medicine University of Queensland Brisbane Qld Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2004-0022"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1210\/jcem.83.2.4594","article-title":"Growth hormone deficiency in adulthood and the effects of growth hormone replacement: a review. 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