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We aimed to investigate the association of easily obtainable clinical subject characteristics such as maternal age, <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>, smoking status, ethnicity, parity and gestational age at blood sampling with the risk of low free thyroxine (<jats:styled-content style=\"fixed-case\">FT<\/jats:styled-content>4) and elevated thyroid stimulating hormone (<jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content>), determined according to the 2\u00b75th\u201397\u00b75th reference range in <jats:styled-content style=\"fixed-case\">TPOA<\/jats:styled-content>b negative women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>, nonsmoking and ethnicity were risk factors for elevated <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content> levels; however, the discriminative ability was poor (range <jats:italic>c<\/jats:italic>\u2010statistic of 0\u00b757\u20130\u00b760). Sensitivity analysis showed that addition of <jats:styled-content style=\"fixed-case\">TPOA<\/jats:styled-content>bs to the model yielded a <jats:italic>c<\/jats:italic>\u2010statistic of 0\u00b773\u20130\u00b775. Maternal age, <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>, smoking, parity and gestational age at blood sampling were risk factors for low <jats:styled-content style=\"fixed-case\">FT<\/jats:styled-content>4, which taken together provided adequate discrimination (range <jats:italic>c<\/jats:italic>\u2010statistic of 0\u00b772\u20130\u00b776).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Elevated <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content> levels depend predominantly on <jats:styled-content style=\"fixed-case\">TPOA<\/jats:styled-content>b levels, and prediction of elevated <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content> levels is not possible with clinical characteristics only. In contrast, the validated clinical prediction model for <jats:styled-content style=\"fixed-case\">FT<\/jats:styled-content>4 had high discriminative value to assess the likelihood of low <jats:styled-content style=\"fixed-case\">FT<\/jats:styled-content>4 levels.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13153","type":"journal-article","created":{"date-parts":[[2016,7,7]],"date-time":"2016-07-07T07:53:01Z","timestamp":1467877981000},"page":"902-909","source":"Crossref","is-referenced-by-count":29,"title":["Risk factors and a clinical prediction model for low maternal thyroid function during early pregnancy: two population\u2010based prospective cohort studies"],"prefix":"10.1111","volume":"85","author":[{"given":"Tim I.M.","family":"Korevaar","sequence":"first","affiliation":[{"name":"The Generation R Study Group Erasmus University Medical Center \u2013 Sophia Children's Hospital Rotterdam The Netherlands"},{"name":"Department of Internal Medicine Erasmus University Medical Center 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Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Medici","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Erasmus University Medical Center \u2013 Sophia Children's Hospital Rotterdam The Netherlands"},{"name":"Rotterdam Thyroid Center Erasmus University Medical Center \u2013 Sophia Children's Hospital Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Layal","family":"Chaker","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Erasmus University Medical Center \u2013 Sophia Children's Hospital Rotterdam The Netherlands"},{"name":"Rotterdam Thyroid Center Erasmus University Medical Center \u2013 Sophia Children's Hospital Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda B.","family":"de Rijke","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Erasmus University 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