{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T21:20:07Z","timestamp":1770499207045,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,9,22]],"date-time":"2016-09-22T00:00:00Z","timestamp":1474502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Antithyroid drugs (<jats:styled-content style=\"fixed-case\">ATD<\/jats:styled-content>s) are widely used for the treatment of Graves\u2019 disease (<jats:styled-content style=\"fixed-case\">GD<\/jats:styled-content>) in the general population. Over the past decade, there has been an increasing awareness that several disturbances of thyroid function may occur in mothers after delivery which may be more prevalent than previously appreciated. Exacerbation of immune reactions occurs 3\u201312 month following delivery. Management of hyperthyroidism during lactation requires special considerations and should be implemented to prevent any adverse outcomes in mother and neonate. Continuation of breastfeeding is safe and should be encouraged in hyperthyroid mothers taking <jats:styled-content style=\"fixed-case\">ATD<\/jats:styled-content>s, whether these are <jats:styled-content style=\"fixed-case\">ATD<\/jats:styled-content>s being continued after gestation or indeed <jats:styled-content style=\"fixed-case\">ATD<\/jats:styled-content> treatment initiated in the postpartum period. Given <jats:styled-content style=\"fixed-case\">PTU<\/jats:styled-content> hepatotoxicity concerns, experts currently recommend using low\u2010to\u2010moderate <jats:styled-content style=\"fixed-case\">MMI<\/jats:styled-content> doses as a first\u2010line therapy in lactating mothers. <jats:styled-content style=\"fixed-case\">PTU<\/jats:styled-content> should be reserved only as a second\u2010line agent for cases of severe hyperthyroidism (thyroid storm) and allergic reactions to previous <jats:styled-content style=\"fixed-case\">MMI<\/jats:styled-content> treatment. <jats:styled-content style=\"fixed-case\">ATD<\/jats:styled-content> should be administered in divided doses immediately following each feeding. Evaluation of thyroid function tests is advisable at least 3\u20134 weeks after the initiation of breastfeeding.<\/jats:p>","DOI":"10.1111\/cen.13176","type":"journal-article","created":{"date-parts":[[2016,8,26]],"date-time":"2016-08-26T08:16:55Z","timestamp":1472199415000},"page":"827-830","source":"Crossref","is-referenced-by-count":11,"title":["Antithyroid drugs during breastfeeding"],"prefix":"10.1111","volume":"85","author":[{"given":"Bartosz","family":"Hudzik","sequence":"first","affiliation":[{"name":"Third Department of Cardiology Silesian Centre for Heart Disease SMDZ in Zabrze Medical University of Silesia in Katowice Zabrze Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Zubelewicz\u2010Szkodzinska","sequence":"additional","affiliation":[{"name":"Department of Nutrition\u2010Related Disease Prevention School of Public Health in Bytom Medical University of Silesia in Katowice Bytom Poland"},{"name":"Department of Endocrinology County Hospital Piekary Slaskie Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9,22]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"CD003517","article-title":"Optimal duration of exclusive breastfeeding","volume":"8","author":"Kramer M.S.","year":"2012","journal-title":"Cochrane Database Systematic Review"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra042972"},{"key":"e_1_2_5_4_1","doi-asserted-by":"crossref","first-page":"2354","DOI":"10.1210\/jcem.86.6.7573","article-title":"The use of antithyroid drugs in pregnancy and lactation","volume":"86","author":"Mandel S.J.","year":"2001","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI101532"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(80)91233-7"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00613617"},{"key":"e_1_2_5_8_1","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1210\/jcem.85.9.6810","article-title":"Thyroid function and intellectual development of infants nursed by mothers taking methimazole","volume":"85","author":"Azizi F.","year":"2000","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000336595"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2000.01078.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03345489"},{"key":"e_1_2_5_12_1","first-page":"155","article-title":"Management of hyperthyroidism and goitre in pregnancy, and postpartum thyroiditis","volume":"31","author":"Lao T.","year":"2005","journal-title":"Journal of Paediatrics Obstetrics and Gynaecology"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200007133430208"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2011.0087"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-0141"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1676"},{"key":"e_1_2_5_17_1","unstructured":"Krishna U.R. Tank D.K.&Daftary S.(2001)Pregnancy at risk: current concepts.New Delhi:Jaypee (2004 [printing])."},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc0809750"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03469.x"},{"key":"e_1_2_5_20_1","unstructured":"U.S. Food and Drug Administration (2009 Propylthiouracyl (PTU)\u2010related liver toxicity. April 18 2009 workshop)."},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(96)70342-6"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.14310\/horm.2002.1248"},{"key":"e_1_2_5_23_1","first-page":"797","article-title":"Pharmacologic treatment of hyperthyroidism during lactation","volume":"55","author":"Glatstein M.M.","year":"2009","journal-title":"Canadian Family Physician"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcen.13176","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcen.13176","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.13176","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T08:20:20Z","timestamp":1695543620000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.13176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,22]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1111\/cen.13176"],"URL":"https:\/\/doi.org\/10.1111\/cen.13176","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,22]]}}}