{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T21:54:11Z","timestamp":1785534851422,"version":"3.56.0"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,10,25]],"date-time":"2016-10-25T00:00:00Z","timestamp":1477353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Context<\/jats:title><jats:p>Patients with Prader\u2013Willi syndrome (<jats:styled-content style=\"fixed-case\">PWS<\/jats:styled-content>) have an increased fat mass and decreased lean body mass. <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content>\u2010treated young adults with <jats:styled-content style=\"fixed-case\">PWS<\/jats:styled-content> who have attained adult height benefit from continuation of growth hormone (<jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content>) treatment, as <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content> maintained their improved body composition, whereas fat mass increased during the placebo period. Adults with <jats:styled-content style=\"fixed-case\">PWS<\/jats:styled-content> are predisposed to T2<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> and cardiovascular disease. Whether <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content> affects metabolic health profile of this patient group is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the effects of <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content> <jats:italic>vs<\/jats:italic> placebo on metabolic health, in young adults with <jats:styled-content style=\"fixed-case\">PWS<\/jats:styled-content> who were <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content>\u2010treated for many years during childhood and had attained adult height (<jats:styled-content style=\"fixed-case\">AH<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A 2\u2010year, randomized, double\u2010blind, placebo\u2010controlled crossover study with stratification for gender and <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> in 27 young adults with <jats:styled-content style=\"fixed-case\">PWS<\/jats:styled-content>. Intervention with <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content> (0\u00b767 mg\/m<jats:sup>2<\/jats:sup>\/day) and placebo, both for 1\u2010year duration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to placebo, <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content> treatment resulted in similar glucose and insulin levels during oral glucose tolerance test. Only fasting glucose and insulin were slightly higher during <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content> <jats:italic>vs<\/jats:italic> placebo (+0\u00b72 mmol\/l and +18\u00b74 pmol\/l), although both remained within normal ranges in both phases. Blood pressure and lipid profile were similar after <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content> <jats:italic>vs<\/jats:italic> placebo. At baseline (<jats:styled-content style=\"fixed-case\">AH<\/jats:styled-content>) and during <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content>, no patients had metabolic syndrome, while 1 developed it during placebo treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Growth hormone treatment has no adverse effects on metabolic health profile. Thus, <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content>\u2010treated young adults with <jats:styled-content style=\"fixed-case\">PWS<\/jats:styled-content> who have attained <jats:styled-content style=\"fixed-case\">AH<\/jats:styled-content> benefit from continuation of <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content> treatment without safety concerns regarding metabolic health.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13247","type":"journal-article","created":{"date-parts":[[2016,10,7]],"date-time":"2016-10-07T08:08:35Z","timestamp":1475827715000},"page":"297-304","source":"Crossref","is-referenced-by-count":20,"title":["Metabolic health profile in young adults with Prader\u2013Willi syndrome: results of a 2\u2010year randomized, placebo\u2010controlled, crossover <scp>GH<\/scp> trial"],"prefix":"10.1111","volume":"86","author":[{"given":"R.J.","family":"Kuppens","sequence":"first","affiliation":[{"name":"Dutch Growth Research Foundation 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