{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T04:27:29Z","timestamp":1768624049609,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,10,21]],"date-time":"2016-10-21T00:00:00Z","timestamp":1477008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Identification of the novel endocrine role of osteocalcin (<jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>) and its receptor <jats:styled-content style=\"fixed-case\">GPRC<\/jats:styled-content>6A has given rise to a new branch of research in <jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">GPRC<\/jats:styled-content>6A axis related to glucose metabolism. <jats:styled-content style=\"fixed-case\">GPRC<\/jats:styled-content>6A\u2010 and <jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>\u2010deficient mice share features of the metabolic syndrome, in addition to male infertility. Recently, the polymorphism <jats:italic>rs2274911<\/jats:italic> in <jats:italic><jats:styled-content style=\"fixed-case\">GPRC<\/jats:styled-content>6A<\/jats:italic> was shown to be associated with testicular impairment. We aimed to investigate the role of <jats:italic>rs2274911<\/jats:italic> polymorphism in glucose and lipid metabolism in a cohort of normal weight and obese subjects<\/jats:p><\/jats:sec><jats:sec><jats:title>Design, Patients, Settings<\/jats:title><jats:p>A total of 392 male and females, including 218 obese patients and 174 age\u2010matched normal weight controls, were retrospectively selected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The distribution of <jats:italic>rs2274911<\/jats:italic> alleles and genotypes did not differ either between normal weight and obese subjects or sexes (all <jats:italic>P<\/jats:italic> &gt; 0\u00b705). Age\u2010 and <jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>\u2010adjusted multivariate analysis revealed that, in the normal weight group, fasting insulin and <jats:styled-content style=\"fixed-case\">HOMA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content> increased in <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> (<jats:italic>P<\/jats:italic> = 0\u00b7016 and <jats:italic>P<\/jats:italic> = 0\u00b7025) and <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> genotypes (<jats:italic>P<\/jats:italic> = 0\u00b7033 and <jats:italic>P<\/jats:italic> = 0\u00b7040) compared with <jats:styled-content style=\"fixed-case\">GG<\/jats:styled-content> homozygotes. In the obese group, <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> homozygotes had increased fasting glucose (<jats:italic>P<\/jats:italic> = 0\u00b7041 <jats:italic>vs <\/jats:italic><jats:styled-content style=\"fixed-case\">GG<\/jats:styled-content>). Triglycerides, fasting insulin and <jats:styled-content style=\"fixed-case\">HOMA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content> increased in both <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> (<jats:italic>P<\/jats:italic> = 0\u00b7020, <jats:italic>P<\/jats:italic> &lt; 0\u00b7001 and <jats:italic>P<\/jats:italic> = 0\u00b7001) and <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> genotype (<jats:italic>P<\/jats:italic> = 0\u00b7021, <jats:italic>P<\/jats:italic> = 0\u00b7013 and <jats:italic>P<\/jats:italic> = 0\u00b7013).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In a cohort of normal weight and obese subjects, we found that the nonrare polymorphism <jats:italic>rs2274911<\/jats:italic> in the <jats:italic><jats:styled-content style=\"fixed-case\">GPRC<\/jats:styled-content>6A<\/jats:italic> gene was associated with insulin resistance features, independently of the metabolic phenotype and <jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content> levels.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13248","type":"journal-article","created":{"date-parts":[[2016,10,7]],"date-time":"2016-10-07T12:35:11Z","timestamp":1475843711000},"page":"185-191","source":"Crossref","is-referenced-by-count":32,"title":["The <i>rs2274911<\/i> polymorphism in <i><scp>GPRC<\/scp>6A<\/i> gene is associated with insulin resistance in normal weight and obese subjects"],"prefix":"10.1111","volume":"86","author":[{"given":"Andrea","family":"Di Nisio","sequence":"first","affiliation":[{"name":"Department of Medicine Unit of Andrology and Reproductive Medicine University of Padova Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Santa","family":"Rocca","sequence":"additional","affiliation":[{"name":"Department of Medicine Unit of Andrology and Reproductive Medicine University of Padova Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gian Paolo","family":"Fadini","sequence":"additional","affiliation":[{"name":"Division of Metabolic Diseases Department of Medicine University of Padova Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"De Toni","sequence":"additional","affiliation":[{"name":"Department of Medicine Unit of Andrology and Reproductive Medicine University of Padova Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Marcuzzo","sequence":"additional","affiliation":[{"name":"Department of Cardiologic, Thoracic and Vascular Sciences Service of Preventive Medicine University of Padova Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Cristina","family":"Marescotti","sequence":"additional","affiliation":[{"name":"Division of Metabolic Diseases Department of Medicine University of Padova Padova 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