{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T22:15:46Z","timestamp":1793744146002,"version":"4.6.1"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T00:00:00Z","timestamp":1484006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Vice-chancellor for Research, KUMS, Iran"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Data on the effects of coenzyme Q10 (CoQ10) supplementation on metabolic profiles among subjects with polycystic ovary syndrome (PCOS) are scarce.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study was carried out to evaluate the effects of CoQ10 supplementation on glucose metabolism and lipid profiles in subjects with PCOS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design, patients and measurements<\/jats:title><jats:p>This randomized, double\u2010blind, placebo\u2010controlled trial was conducted on 60 women diagnosed with PCOS. Subjects were randomly assigned into two groups to intake either 100 mg CoQ10 supplements (<jats:italic>N<\/jats:italic> = 30) or placebo (<jats:italic>N<\/jats:italic> = 30) per day for 12 weeks. Markers of insulin metabolism and lipid profiles were assessed at first and 12 weeks after the intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 12 weeks of intervention, compared to the placebo, subjects who received CoQ10 supplements had significantly decreased fasting plasma glucose (\u22120\u00b724 \u00b1 0\u00b751 <jats:italic>vs<\/jats:italic> +0\u00b701 \u00b1 0\u00b744 mmol\/l, <jats:italic>P<\/jats:italic> = 0\u00b704), serum insulin concentrations (\u22127\u00b78 \u00b1 14\u00b74 <jats:italic>vs<\/jats:italic> +6\u00b70 \u00b1 15\u00b70 pmol\/l, <jats:italic>P<\/jats:italic> &lt; 0\u00b7001), the homeostasis model of assessment\u2010estimated insulin resistance (\u22120\u00b73 \u00b1 0\u00b76 <jats:italic>vs<\/jats:italic> +0\u00b72 \u00b1 0\u00b76, <jats:italic>P<\/jats:italic> = 0\u00b7001), the homeostasis model of assessment\u2010estimated B\u2010cell function (\u22125\u00b74 \u00b1 9\u00b75 <jats:italic>vs<\/jats:italic> +4\u00b75 \u00b1 9\u00b79, <jats:italic>P<\/jats:italic> &lt; 0\u00b7001) and increased the quantitative insulin sensitivity check index (+0\u00b7006 \u00b1 0\u00b7009 <jats:italic>vs<\/jats:italic> \u22120\u00b7006 \u00b1 0\u00b701, <jats:italic>P<\/jats:italic> &lt; 0\u00b7001). In addition, changes in serum total\u2010 (\u22120\u00b710 \u00b1 0\u00b748 <jats:italic>vs<\/jats:italic> +0\u00b719 \u00b1 0\u00b750 mmol\/l, <jats:italic>P<\/jats:italic> = 0\u00b702) and LDL\u2010cholesterol concentrations (\u22120\u00b715 \u00b1 0\u00b740 <jats:italic>vs<\/jats:italic> +0\u00b714 \u00b1 0\u00b749 mmol\/l, <jats:italic>P<\/jats:italic> = 0\u00b701) in supplemented women were significantly different from those of women in the placebo group. When we adjusted the analysis for baseline values of biochemical parameters, age and baseline BMI, serum LDL\u2010cholesterol (<jats:italic>P<\/jats:italic> = 0\u00b705) became nonsignificant, and other findings did not alter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Overall, CoQ10 supplementation for 12 weeks among subjects with PCOS had beneficial effects on glucose metabolism, serum total\u2010 and LDL\u2010cholesterol levels.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13288","type":"journal-article","created":{"date-parts":[[2016,12,2]],"date-time":"2016-12-02T16:05:53Z","timestamp":1480694753000},"page":"560-566","source":"Crossref","is-referenced-by-count":46,"title":["The effects of coenzyme Q10 supplementation on glucose metabolism and lipid profiles in women with polycystic ovary syndrome: a randomized, double\u2010blind, placebo\u2010controlled 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