{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:40:42Z","timestamp":1773297642591,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,2,3]],"date-time":"2017-02-03T00:00:00Z","timestamp":1486080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Hypopituitarism diagnosed in childhood, adolescence and young adulthood has the potential to affect growth and somatic development. Less is known about the impact of such a diagnosis on other aspects of development.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>An analysis of the <jats:styled-content style=\"fixed-case\">KIMS<\/jats:styled-content> database (Pfizer International Metabolic Database) was performed to explore social, educational and vocational outcomes of adult patients diagnosed in childhood, adolescence and young adulthood compared with adult\u2010onset controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>A total of 2952 adult patients diagnosed with hypothalamic pituitary conditions before the age of 25 were divided into two groups: childhood\u2010onset [&lt;16 years (<jats:styled-content style=\"fixed-case\">CO<\/jats:styled-content>)] (<jats:italic>n<\/jats:italic> = 1782) and young\u2010adult\u2010onset [16 to &lt;25 years (<jats:styled-content style=\"fixed-case\">YAO<\/jats:styled-content>)] (<jats:italic>n<\/jats:italic> = 1170). A total of 1617 adult patients diagnosed with a nonfunctioning pituitary adenoma at the age of 25 or older formed the adult\u2010onset control group (<jats:styled-content style=\"fixed-case\">AO<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">KIMS<\/jats:styled-content> Patient Life Situation Form which provided information on social, educational and vocational outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with the <jats:styled-content style=\"fixed-case\">AO<\/jats:styled-content> control group, <jats:styled-content style=\"fixed-case\">CO<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">YAO<\/jats:styled-content> patients were between 4\u00b75 and 8\u00b70 times more likely to live with their parents in adulthood; <jats:styled-content style=\"fixed-case\">CO<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">YAO<\/jats:styled-content> patients were also less likely to live in partnership and to have children. The impact on educational and vocational outcomes was less marked than on social outcomes with no significant differences compared with the <jats:styled-content style=\"fixed-case\">AO<\/jats:styled-content> control group. Educational and vocational outcomes showed the lowest level in male and female <jats:styled-content style=\"fixed-case\">CO<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">YAO<\/jats:styled-content> patients who had been previously diagnosed with a brain tumour.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Social outcomes were more affected than educational and vocational outcomes. Although <jats:styled-content style=\"fixed-case\">CO<\/jats:styled-content> patients are more adversely affected, <jats:styled-content style=\"fixed-case\">YAO<\/jats:styled-content> patients were also failing to achieve social milestones. This has consequences for the delivery of endocrine care in both paediatric and adult services.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13291","type":"journal-article","created":{"date-parts":[[2016,12,17]],"date-time":"2016-12-17T11:49:12Z","timestamp":1481975352000},"page":"526-533","source":"Crossref","is-referenced-by-count":8,"title":["Social, educational and vocational outcomes in patients with childhood\u2010onset and young\u2010adult\u2010onset growth hormone deficiency"],"prefix":"10.1111","volume":"86","author":[{"given":"M. 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