{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:36:42Z","timestamp":1783489002452,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,1,26]],"date-time":"2017-01-26T00:00:00Z","timestamp":1485388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Isolated maternal hypothyroxinaemia (<jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content>) is defined as low maternal <jats:styled-content style=\"fixed-case\">FT<\/jats:styled-content>4 (&lt;5th percentile) and normal thyroid\u2010stimulating hormone. There is concern on its potential negative effects on the mother and offspring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to evaluate the prevalence of <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content> and to assess the consequences of hypothyroxinaemia on the maternal and foetal outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and methods<\/jats:title><jats:p>From a total of 1300 consecutive pregnant women recruited during the prenatal screen (mean gestational age, 11\u00b78 weeks), thyroid function parameters were assessed in 879 women. After exclusion of women with T4 supplements, with twin pregnancies and with diabetes, data from 783 women were included. Maternal and neonatal outcomes in 55 selected women with <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content> and negative thyroid auto\u2010antibodies without thyroid disorders or pregnancy achieved through assisted reproductive techniques were compared with a selected euthyroid control group (<jats:italic>N<\/jats:italic> = 165).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 783 non diabetic singleton pregnant women, 68 women (8\u00b77%) were identified with <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content>. When compared to the selected euthyroid controls, selected women with hypothyroxinaemia had significantly increased body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>) in preconception (<jats:italic>P<\/jats:italic> = 0\u00b7003), in the first trimester (<jats:italic>P<\/jats:italic> = 0\u00b7004) and at the time of delivery (<jats:italic>P<\/jats:italic> = 0\u00b7001). At term, foetal breech presentation and caesarean section rate were significantly higher (<jats:italic>P<\/jats:italic> = 0\u00b7006 and <jats:italic>P<\/jats:italic> = 0\u00b7026, respectively) than in the euthyroid controls. A significant increase in macrosomia was also noted (<jats:italic>P<\/jats:italic> = 0\u00b7026).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prevalence of hypothyroxinaemia in early pregnancy was of 8\u00b77%. <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content> is associated with an increased maternal <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> and is related with a risk of breech presentation, a significant increase in macrosomia and caesarean sections. Screening should consider overweight as risk factor for hypothyroxinaemia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13301","type":"journal-article","created":{"date-parts":[[2016,12,31]],"date-time":"2016-12-31T07:26:45Z","timestamp":1483169205000},"page":"576-583","source":"Crossref","is-referenced-by-count":22,"title":["First trimester isolated maternal hypothyroxinaemia: adverse maternal metabolic profile and impact on the obstetrical outcome"],"prefix":"10.1111","volume":"86","author":[{"given":"Raluca M.","family":"Furnica","sequence":"first","affiliation":[{"name":"Department of Endocrinology Universit\u00e9 catholique de Louvain Cliniques Universitaires Saint\u2010Luc Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Gruson","sequence":"additional","affiliation":[{"name":"Department of Clinical Biology Universit\u00e9 catholique de Louvain Cliniques Universitaires Saint\u2010Luc Brussels 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Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5706-0504","authenticated-orcid":false,"given":"Chantal","family":"Daumerie","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Universit\u00e9 catholique de Louvain Cliniques Universitaires Saint\u2010Luc Brussels 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