{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:05:54Z","timestamp":1790690754224,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T00:00:00Z","timestamp":1486684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Context<\/jats:title><jats:p>Due to the central role of metabolic abnormalities in the pathophysiology of polycystic ovary syndrome (<jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>), insulin sensitizing agents have been proposed as a feasible treatment option.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate which is the more effective between metformin and myoinositol (MYO) on hormonal, clinical and metabolic parameters in obese patients with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design<\/jats:title><jats:p>Crossover randomized controlled study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>Thirty\u2010four <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> obese women (age: 25\u00b762 \u00b1 4\u00b77 years; <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>: 32\u00b755 \u00b1 5\u00b767 kg\/m<jats:sup>2<\/jats:sup>) were randomized to receive metformin (850 mg twice a day) or MYO (1000 mg twice a day) for 6 months. After a 3 month washout, the same subjects received the other compound for the following 6 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Ultrasonographic pelvic examinations, hirsutism score, anthropometric and menstrual pattern evaluation, hormonal profile assays, oral glucose tolerance test (<jats:styled-content style=\"fixed-case\">OGTT<\/jats:styled-content>) and lipid profile at baseline and after 6 months of treatment were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both metformin and MYO significantly reduced the insulin response to <jats:styled-content style=\"fixed-case\">OGTT<\/jats:styled-content> and improved insulin sensitivity. Metformin significantly decreased body weight and improved menstrual pattern and Ferriman\u2013Gallwey score. Metformin treatment was also associated with a significant decrease in <jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content> and oestradiol levels, androgens and anti\u2010m\u00fcllerian hormone levels. None of these clinical and hormonal changes were observed during MYO administration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both treatments improved the glyco\u2010insulinaemic features of obese <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> patients, but only metformin seems to exert a beneficial effect on the endocrine and clinical features of the syndrome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13304","type":"journal-article","created":{"date-parts":[[2017,1,16]],"date-time":"2017-01-16T17:15:44Z","timestamp":1484586944000},"page":"725-730","source":"Crossref","is-referenced-by-count":30,"title":["Metformin <i>vs<\/i> myoinositol: which is better in obese polycystic ovary syndrome patients? A randomized controlled crossover study"],"prefix":"10.1111","volume":"86","author":[{"given":"Valeria","family":"Tagliaferri","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Universit\u00e0 Cattolica del Sacro Cuore Roma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Romualdi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Universit\u00e0 Cattolica del Sacro Cuore Roma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8241-3949","authenticated-orcid":false,"given":"Valentina","family":"Immediata","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Universit\u00e0 Cattolica del Sacro Cuore Roma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"De Cicco","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Universit\u00e0 Cattolica del Sacro Cuore Roma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Di Florio","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Universit\u00e0 Cattolica del Sacro Cuore Roma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Lanzone","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Universit\u00e0 Cattolica del Sacro Cuore Roma Italy"},{"name":"Department of Obstetrics and Gynaecology Ospedale Generale Regionale Ente Ecclesiastico F.Miulli Acquaviva delle Fonti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Guido","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Universit\u00e0 Cattolica del Sacro Cuore Roma Italy"},{"name":"Department of Obstetrics and Gynaecology Ospedale Generale Regionale Ente Ecclesiastico 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