{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:46:41Z","timestamp":1787014001803,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,3,28]],"date-time":"2017-03-28T00:00:00Z","timestamp":1490659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To evaluate obesity and overweight in children with congenital adrenal hyperplasia (\n                      <jats:styled-content style=\"fixed-case\">CAH<\/jats:styled-content>\n                      ) and associations with glucocorticoids, fludrocortisone and disease control. Adjusting body mass index\u2010for\u2010height\u2010age (\n                      <jats:styled-content style=\"fixed-case\">\n                        BMI\n                        <jats:sub>HA<\/jats:sub>\n                      <\/jats:styled-content>\n                      ) percentile is proposed to correct misclassification of obese\/overweight status in\n                      <jats:styled-content style=\"fixed-case\">CAH<\/jats:styled-content>\n                      children with advanced bone age and tall\u2010for\u2010age stature.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Longitudinal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>\n                      One hundred and ninety\u2010four children with\n                      <jats:styled-content style=\"fixed-case\">CAH<\/jats:styled-content>\n                      seen from 1970 to 2013: 124 salt wasting (\n                      <jats:styled-content style=\"fixed-case\">SW<\/jats:styled-content>\n                      ); 70 simple virilizing (\n                      <jats:styled-content style=\"fixed-case\">SV<\/jats:styled-content>\n                      ); 102 females.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>Body mass index (BMI) end\u2010points were overweight (85\u201394 percentile) and obese (\u226595 percentile).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Approximately 50% of the children had at least one\n                      <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>\n                      measurement \u226595 percentile and about 70% had at least one \u226585 percentile. Using\n                      <jats:styled-content style=\"fixed-case\">\n                        BMI\n                        <jats:sub>HA<\/jats:sub>\n                      <\/jats:styled-content>\n                      percentiles, obesity incidence decreased slightly in\n                      <jats:styled-content style=\"fixed-case\">SW<\/jats:styled-content>\n                      children (47\u201343%) and markedly in\n                      <jats:styled-content style=\"fixed-case\">SV<\/jats:styled-content>\n                      children (50\u201333%); however, overweight status was not reduced. Only 6% of\n                      <jats:styled-content style=\"fixed-case\">SW<\/jats:styled-content>\n                      and 1% of\n                      <jats:styled-content style=\"fixed-case\">SV<\/jats:styled-content>\n                      children were persistently obese (\u22653 clinic visits) when\n                      <jats:styled-content style=\"fixed-case\">\n                        BMI\n                        <jats:sub>HA<\/jats:sub>\n                      <\/jats:styled-content>\n                      was applied, whereas overweight status persisted in 35% of\n                      <jats:styled-content style=\"fixed-case\">SW<\/jats:styled-content>\n                      and 33% of\n                      <jats:styled-content style=\"fixed-case\">SV<\/jats:styled-content>\n                      children. Most obesity or overweight when using\n                      <jats:styled-content style=\"fixed-case\">\n                        BMI\n                        <jats:sub>HA<\/jats:sub>\n                      <\/jats:styled-content>\n                      occurred before age 10 and there was no association with hydrocortisone (HC) or fludrocortisone dosing. Adiposity rebound for\n                      <jats:styled-content style=\"fixed-case\">SW<\/jats:styled-content>\n                      children occurred by 3\u00b73 years and in\n                      <jats:styled-content style=\"fixed-case\">SV<\/jats:styled-content>\n                      females by age 3\u00b78 years, over a year earlier than the adiposity rebound for healthy children.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Children with\n                      <jats:styled-content style=\"fixed-case\">CAH<\/jats:styled-content>\n                      are at higher risk for early onset obesity and overweight with or without using\n                      <jats:styled-content style=\"fixed-case\">\n                        BMI\n                        <jats:sub>HA<\/jats:sub>\n                      <\/jats:styled-content>\n                      but rates of persistent obesity were lower than previously reported. Careful HC dosing during early childhood is needed to prevent increased weight gain and an early adiposity rebound.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.13313","type":"journal-article","created":{"date-parts":[[2017,2,15]],"date-time":"2017-02-15T12:39:53Z","timestamp":1487162393000},"page":"708-716","source":"Crossref","is-referenced-by-count":41,"title":["Obesity in children with congenital adrenal hyperplasia in the Minnesota cohort: importance of adjusting body mass index for height\u2010age"],"prefix":"10.1111","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5741-3629","authenticated-orcid":false,"given":"Kyriakie","family":"Sarafoglou","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of Minnesota Masonic Children's Hospital Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory 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