{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:53:00Z","timestamp":1761519180922,"version":"3.37.3"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,5,5]],"date-time":"2017-05-05T00:00:00Z","timestamp":1493942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Normal or elevated 24\u2010hour urinary calcium (Ca) excretion is a diagnostic marker in primary hyperparathyroidism (<jats:styled-content style=\"fixed-case\">PHPT<\/jats:styled-content>). It is used to distinguish familial hypocalciuric hypercalcaemia (<jats:styled-content style=\"fixed-case\">FHH<\/jats:styled-content>) from <jats:styled-content style=\"fixed-case\">PHPT<\/jats:styled-content> by calculating the Ca\/creatinine clearance ratio (<jats:styled-content style=\"fixed-case\">CCCR<\/jats:styled-content>). The variance of <jats:styled-content style=\"fixed-case\">CCCR<\/jats:styled-content> in patients with <jats:styled-content style=\"fixed-case\">PHPT<\/jats:styled-content> is considerable. The aim of this study was to analyse the parameters affecting <jats:styled-content style=\"fixed-case\">CCCR<\/jats:styled-content> in patients with <jats:styled-content style=\"fixed-case\">PHPT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>The data were collected prospectively. Patients with sporadic <jats:styled-content style=\"fixed-case\">PHPT<\/jats:styled-content> undergoing successful surgery were included in a retrospective analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>The analysis covered 381 patients with pre\u2010operative workup 2\u00a0days before removal of a solitary parathyroid adenoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>The impact of serum Ca and 25\u2010hydroxyvitamin D3 (25\u2010<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content> D3) on <jats:styled-content style=\"fixed-case\">CCCR<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The coefficient of determination (R<jats:sup>2<\/jats:sup>) in the multivariable model for <jats:styled-content style=\"fixed-case\">CCCR<\/jats:styled-content> consisting of age, Ca, 25\u2010<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content> D3, 1,25\u2010dihydroxyvitamin D3 (1,25\u2010(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)2 D3), testosterone (separately for males and females), intact parathyroid hormone (<jats:styled-content style=\"fixed-case\">iPTH<\/jats:styled-content>) and osteocalcin was 25.8%. The only significant parameters in the multivariable analysis were 1,25\u2010(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)2 D3 and osteocalcin with a drop in <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> of 15.4% (<jats:italic>P<\/jats:italic>&lt;.001) and 2.4% (<jats:italic>P<\/jats:italic>=.006), respectively. Bone mineral densities at the lumbar spine, distal radius and left femoral neck were not associated with <jats:styled-content style=\"fixed-case\">CCCR<\/jats:styled-content> (<jats:italic>r<\/jats:italic>=\u2212.08, <jats:italic>r<\/jats:italic>=\u2212.10 and <jats:italic>r<\/jats:italic>=\u22120.09).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In multivariable analysis, 1,25\u2010(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)2 D3 and osteocalcin were the only factors correlating with <jats:styled-content style=\"fixed-case\">CCCR<\/jats:styled-content>. Vitamin D3 replacement may therefore impair the diagnostic value of <jats:styled-content style=\"fixed-case\">CCCR<\/jats:styled-content> and increase the importance of close monitoring of urinary Ca excretion during treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13348","type":"journal-article","created":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T17:22:59Z","timestamp":1491499379000},"page":"97-102","source":"Crossref","is-referenced-by-count":2,"title":["Factors influencing pre\u2010operative urinary calcium excretion in primary hyperparathyroidism"],"prefix":"10.1111","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8190-8771","authenticated-orcid":false,"given":"Reto M.","family":"Kaderli","sequence":"first","affiliation":[{"name":"Section of Endocrine Surgery Division of General Surgery Department of Surgery Medical University of Vienna  Wien Austria"},{"name":"Department of Visceral Surgery and Medicine Inselspital Bern University Hospital University 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