{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T13:57:09Z","timestamp":1760623029120,"version":"3.37.3"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,5,11]],"date-time":"2017-05-11T00:00:00Z","timestamp":1494460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004963","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["613977"],"award-info":[{"award-number":["613977"]}],"id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Observational studies have suggested positive associations between serum 25\u2010hydroxyvitamin D (25(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)D) levels and muscular strength, balance and quality of life. Our aim was to examine whether high\u2010dose vitamin D supplementation would improve these measures as compared to standard\u2010dose vitamin D, as well as the possible muscular effects of single nucleotide polymorphisms (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s) in genes encoding vitamin D\u2010related enzymes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A 12\u2010month randomized, double\u2010blind, controlled trial where the participants received daily elemental calcium (1000\u00a0mg) plus vitamin D<jats:sub>3<\/jats:sub> (800\u00a0<jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>). In addition, the participants were randomized to receive either capsules with vitamin D<jats:sub>3<\/jats:sub> (20\u00a0000\u00a0<jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>) or matching placebos to be taken twice a week.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>A total of 297 postmenopausal women with osteopenia or osteoporosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Muscle strength (handgrip and knee extensor strength), balance (tandem test) and quality of life (<jats:styled-content style=\"fixed-case\">EQ<\/jats:styled-content>\u20105D) were measured at baseline and after 12\u00a0months. The subjects were genotyped for <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s related to vitamin D metabolism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 297 included women, 275 completed the study. Mean serum 25(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)D levels dramatically increased in the high\u2010dose group (from 64.7 to 164.1\u00a0nmol\/L; <jats:italic>P<\/jats:italic>&lt;.01), while a more moderate increased was observed in the standard\u2010dose group (from 64.1 to 81.8\u00a0nmol\/L; <jats:italic>P<\/jats:italic>&lt;.01). There was no significant difference between the groups in change in muscular strength, balance or quality of life over the intervention period. Polymorphisms in rs3829251 (located in the 7\u2010dehydrocholesterol reductase gene) were associated with muscle strength and treatment effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>One\u2010year treatment with high\u2010dose vitamin D had no effect on muscular strength, balance or quality of life in postmenopausal women with osteopenia or osteoporosis as compared to standard dose. The association between rs3829251 and muscle strength needs confirmation in other populations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13353","type":"journal-article","created":{"date-parts":[[2017,4,19]],"date-time":"2017-04-19T23:02:48Z","timestamp":1492642968000},"page":"20-28","source":"Crossref","is-referenced-by-count":12,"title":["The effect of high\u2010dose vitamin D supplementation on muscular function and quality of life in postmenopausal women\u2014A randomized controlled trial"],"prefix":"10.1111","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2292-9489","authenticated-orcid":false,"given":"G.","family":"Grimnes","sequence":"first","affiliation":[{"name":"Troms\u00f8 Endocrine Research Group Institute of Clinical Medicine UiT The Arctic University of Norway  Troms\u00f8 Norway"},{"name":"Division of Internal Medicine University Hospital of North Norway  Troms\u00f8 Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Emaus","sequence":"additional","affiliation":[{"name":"Department of Health and Care Sciences UiT The Arctic University of Norway  Troms\u00f8 Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.D.","family":"Cashman","sequence":"additional","affiliation":[{"name":"Cork Centre for Vitamin D and Nutrition Research School of Food and Nutritional Sciences  Cork Ireland"},{"name":"Department of Medicine University College Cork  Cork Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Jorde","sequence":"additional","affiliation":[{"name":"Troms\u00f8 Endocrine Research Group Institute of Clinical Medicine UiT The Arctic University of Norway  Troms\u00f8 Norway"},{"name":"Division of Internal Medicine University Hospital of North Norway  Troms\u00f8 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