{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:31:46Z","timestamp":1790015506185,"version":"4.0.1"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,5,22]],"date-time":"2017-05-22T00:00:00Z","timestamp":1495411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Key Program of Clinical Science, China","award":["WBYZ2011-873"],"award-info":[{"award-number":["WBYZ2011-873"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Primary lymphocytic hypophysitis (<jats:styled-content style=\"fixed-case\">LYH<\/jats:styled-content>) is rare, and it is often evaluated in a small case series. This study aimed to describe the diagnosis and treatment of primary <jats:styled-content style=\"fixed-case\">LYH<\/jats:styled-content> in a larger cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A retrospective study of the diagnosis and treatment of primary <jats:styled-content style=\"fixed-case\">LYH<\/jats:styled-content> was conducted at Peking Union Medical College Hospital from 1999 to 2016.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>Fifty patients (28 histologically diagnosed and 22 clinically\u2010diagnosed) were eligible for inclusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Clinical, endocrine, pathological and imaging findings; therapies and outcomes were assessed. Ordinal logistic regression analysis was used to evaluate the association between the clinical parameters and outcomes (eg, improvements in pituitary function, regression of lesion size on <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> and disease recurrence).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Central diabetes insipidus (<jats:styled-content style=\"fixed-case\">CDI<\/jats:styled-content>) (72.0%) was the most common endocrine dysfunction. Hypogonadotropic hypogonadism was the most frequently observed (60.0%) manifestation of anterior pituitary dysfunction; adrenal insufficiency was the third most common (26.0%) manifestation; and <jats:styled-content style=\"fixed-case\">IGF<\/jats:styled-content>\u20101 axis defects were the least frequent (22.0%). Thickening of the pituitary stalk was the most frequent (96.0%) imaging finding, and 78.0% of the patients exhibited both intrasellar and suprasellar expansion. Pharmacological dose of glucocorticoids was identified to be significantly associated with increased odds of anterior pituitary function improvement. No observed covariates were significantly associated with improvement of <jats:styled-content style=\"fixed-case\">CDI<\/jats:styled-content> and recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The sequence of anterior pituitary deficiencies in Chinese primary <jats:styled-content style=\"fixed-case\">LYH<\/jats:styled-content> patients was atypical (<jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">FSH<\/jats:styled-content>&gt;<jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content>&gt;<jats:styled-content style=\"fixed-case\">ACTH<\/jats:styled-content>&gt;<jats:styled-content style=\"fixed-case\">IGF<\/jats:styled-content>\u20101 axis deficiency). A pharmacological dose of glucocorticoids was significantly associated with the improved anterior pituitary insufficiency.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13354","type":"journal-article","created":{"date-parts":[[2017,4,19]],"date-time":"2017-04-19T23:02:50Z","timestamp":1492642970000},"page":"177-184","source":"Crossref","is-referenced-by-count":65,"title":["Primary lymphocytic hypophysitis: Clinical characteristics and treatment of 50 cases in a single centre in China over 18\u00a0years"],"prefix":"10.1111","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8191-1188","authenticated-orcid":false,"given":"Shuchang","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory of Endocrinology of National Health and Family Planning Commission Department of Endocrinology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing 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