{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T23:09:26Z","timestamp":1784329766462,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,5,22]],"date-time":"2017-05-22T00:00:00Z","timestamp":1495411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK111529"],"award-info":[{"award-number":["R01DK111529"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000041","name":"American Diabetes Association","doi-asserted-by":"publisher","award":["1\u201017\u2010PDF\u2010146"],"award-info":[{"award-number":["1\u201017\u2010PDF\u2010146"]}],"id":[{"id":"10.13039\/100000041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008898","name":"National Space Biomedical Research Institute","doi-asserted-by":"publisher","award":["2010\u20103"],"award-info":[{"award-number":["2010\u20103"]}],"id":[{"id":"10.13039\/100008898","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008130","name":"Pusan National University Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study was to evaluate the association of urine clusterin\/apolipoprotein J (Apo J) with the development and\/or progression of diabetic kidney disease (<jats:styled-content style=\"fixed-case\">DKD<\/jats:styled-content>) in type 2 diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A total of 159 type 2 diabetic patients and 20 nondiabetic subjects with estimated glomerular filtration rate (<jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>) \u226560\u00a0mL\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup> were enrolled. The baseline values of urine clusterin and tubular damage markers were measured. The primary outcome was the annual decline rate in <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>, and secondary outcomes were the development of chronic kidney disease (<jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>) stage 3 or greater and the persistence\/progression of albuminuria. The median follow\u2010up duration of enrolled patients was 3.0 (1.0\u20105.9) years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Baseline clusterin levels in urine were significantly increased in type 2 diabetic subjects compared with those of nondiabetic subjects. The levels of urine clusterin had a significant correlation with urine tubular damage markers. A positive correlation between the annual rate of decline in <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content> and urine clusterin after adjusting for clinical confounding factors was detected. Multivariate analysis further indicated that urine clusterin correlated with the development of <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> stage 3 or greater and persistence\/progression of albuminuria. In type 2 diabetic subjects with albuminuria, urine clusterin remained associated with the annual decline rate in <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content> and the progression of <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> stage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Urine clusterin reflects tubular damage in the early stage of <jats:styled-content style=\"fixed-case\">DKD<\/jats:styled-content>. The increase in urine clusterin along with albuminuria could be an independent predictive marker for the progression of <jats:styled-content style=\"fixed-case\">DKD<\/jats:styled-content> in type 2 diabetes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13360","type":"journal-article","created":{"date-parts":[[2017,4,23]],"date-time":"2017-04-23T11:03:00Z","timestamp":1492945380000},"page":"156-164","source":"Crossref","is-referenced-by-count":24,"title":["Urine clusterin\/apolipoprotein J is linked to tubular damage\u00a0and renal outcomes in patients with type 2 diabetes\u00a0mellitus"],"prefix":"10.1111","volume":"87","author":[{"given":"Sang Soo","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Metabolism Department of Medicine Beth Israel Deaconess Medical Center Harvard Medical School  Boston MA USA"},{"name":"Department of Internal Medicine Pusan National University Hospital  Busan 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