{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T14:52:33Z","timestamp":1763563953238,"version":"3.37.3"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004752","name":"State Government of Victoria","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004752","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Increased fracture rates are observed in renal transplant recipients (RTRs) compared with the general population. Risk factors include age, diabetes, dialysis vintage, immunosuppression and mineral and bone disorders.<jats:sup>1<\/jats:sup> Low serum phosphorus levels occur post\u2010transplantation; however, its relationship with fracture risk has not been evaluated. The purpose of this study was to evaluate risk factors for fracture in <jats:styled-content style=\"fixed-case\">RTR<\/jats:styled-content>s at a single tertiary referral centre.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cross\u2010sectional analysis of 146 patients (75\u00a0M, 71\u00a0F) who had been referred for dual energy X\u2010ray densitometry (<jats:styled-content style=\"fixed-case\">DXA<\/jats:styled-content>) post\u2010renal transplantation was performed. Aetiology of end stage kidney disease (<jats:styled-content style=\"fixed-case\">ESKD<\/jats:styled-content>), duration of dialysis, parathyroidectomy history, immunosuppression regimen, bone mineral density (<jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>), biochemistry and fractures were documented. Statistical analyses included univariable and multivariable regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of patients was 54\u00a0years and mean time post\u2010transplantation 6.7\u00a0years. A total of 79 fractures occurred in 52 patients (35%), with 40 fractures occurring post\u2010transplantation. Ankle\/foot fractures were most common (48%). Lower serum phosphorus levels and declining femoral neck (<jats:styled-content style=\"fixed-case\">FN<\/jats:styled-content>) <jats:italic>T<\/jats:italic>\u2010score and were associated with fractures in both univariable and multivariable regression analyses after adjusting for age, gender, weight, estimated glomerular filtration rate and pre\u2010transplant history of fracture (<jats:italic>P<\/jats:italic>=.011 and <jats:italic>P<\/jats:italic>=.042 respectively). The relationship between serum phosphorus and fracture remained significant independent of <jats:styled-content style=\"fixed-case\">FN <\/jats:styled-content><jats:italic>T<\/jats:italic>\u2010score, parathyroid hormone levels, parathyroidectomy status and prednisolone use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Fracture was common post\u2010renal transplantation. Lower serum phosphorus levels and declining <jats:styled-content style=\"fixed-case\">FN <\/jats:styled-content><jats:italic>T<\/jats:italic>\u2010scores were associated with fractures. The mechanism of this previously unreported observation requires further evaluation in prospective studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13363","type":"journal-article","created":{"date-parts":[[2017,4,27]],"date-time":"2017-04-27T23:41:04Z","timestamp":1493336464000},"page":"141-148","source":"Crossref","is-referenced-by-count":15,"title":["Serum phosphorus levels and fracture following renal transplantation"],"prefix":"10.1111","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0443-7165","authenticated-orcid":false,"given":"Jasna","family":"Aleksova","sequence":"first","affiliation":[{"name":"Department of Endocrinology Monash Health  Melbourne Australia"},{"name":"Hudson Institute for Medical Research  Clayton Melbourne Australia"},{"name":"Department of Medicine School of Clinical Sciences Monash University  Melbourne 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