{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T12:44:44Z","timestamp":1774356284009,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,6,8]],"date-time":"2017-06-08T00:00:00Z","timestamp":1496880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Context<\/jats:title><jats:p>The coexistence of differentiated thyroid cancer (<jats:styled-content style=\"fixed-case\">DTC<\/jats:styled-content>) and thyroid autoimmune disease could represent a better or worse prognosis. This study investigated the prognostic importance of preoperative anti\u2010thyroglobulin antibody (TgAb) in <jats:styled-content style=\"fixed-case\">DTC<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and patients<\/jats:title><jats:p>This retrospective hospital\u2010cohort study enrolled 1171 consecutive <jats:styled-content style=\"fixed-case\">DTC<\/jats:styled-content> patients with preoperative TgAb data, who underwent total thyroidectomy between January 2006 and December 2011. Clinical parameters studied included demographics, primary tumour characteristics, radioiodine therapy, thyroid function tests, preoperative thyroglobulin (Tg) and TgAb levels, and cancer persistence\/recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 254 (21.7%) patients were preoperatively TgAb positive. The percentage positive for thyroid peroxidase (<jats:styled-content style=\"fixed-case\">TPO<\/jats:styled-content>) antibody and lymphocytic thyroiditis was significantly higher in the TgAb\u2010positive group. The TgAb\u2010positive group had a significantly higher rate of lymphatic invasion and lymph node metastasis both overall and in patients without <jats:styled-content style=\"fixed-case\">TPOA<\/jats:styled-content>b and lymphocytic thyroiditis (non\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> group). The mean number of total and central lymph nodes dissected and rate of lateral lymph node dissection were significantly higher in the TgAb\u2010positive group, both overall and in non\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> patients. In regression analysis, preoperative TgAb was an independent risk factor for lateral lymph node metastasis. Over 50.2\u00b114.5\u00a0months of follow\u2010up, disease persistence\/recurrence was not significantly different between patients with and without TgAb, both overall and in non\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> patients. Preoperative TgAb showed no significant correlation with final disease status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Positive preoperative serum TgAb is associated with worse primary tumour characteristics but rarely showed poor prognosis, probably due to more aggressive treatment of these subjects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13367","type":"journal-article","created":{"date-parts":[[2017,5,10]],"date-time":"2017-05-10T20:32:44Z","timestamp":1494448364000},"page":"292-299","source":"Crossref","is-referenced-by-count":24,"title":["Prognostic value of preoperative anti\u2010thyroglobulin antibody in differentiated thyroid cancer"],"prefix":"10.1111","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3308-6560","authenticated-orcid":false,"given":"Kwanhoon","family":"Jo","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism Department of Internal Medicine College of Medicine The Catholic 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