{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:51:05Z","timestamp":1786409465023,"version":"build-2736575974"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,6,8]],"date-time":"2017-06-08T00:00:00Z","timestamp":1496880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000765","name":"University College London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000765","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2017,8]]},"abstract":"\nSummary<\/jats:bold>\n<\/jats:title>Objective<\/jats:title>Low bone mineral density (BMD<\/jats:styled-content>) has been reported in complete androgen insensitivity syndrome (CAIS<\/jats:styled-content>), but the impact of timing of gonadectomy is not known. We aimed to assess the relationship between age of gonadectomy and BMD<\/jats:styled-content> in women with CAIS<\/jats:styled-content>.<\/jats:bold><\/jats:p><\/jats:sec>Design<\/jats:title>Retrospective analysis of pre\u2010 and post\u2010gonadectomy parameters in women with CAIS<\/jats:styled-content> attending an adult Disorders of Sex Development (DSD<\/jats:styled-content>) clinic in a tertiary centre.<\/jats:p><\/jats:sec>Patients<\/jats:title>One hundred and thirteen women with CAIS<\/jats:styled-content>.<\/jats:p><\/jats:sec>Measurements<\/jats:title>Dual\u2010energy X\u2010ray absorptiometry (DXA<\/jats:styled-content>) before and after gonadectomy; and pre\u2010gonadectomy hormone profile.<\/jats:p><\/jats:sec>Results<\/jats:title>Mean BMD<\/jats:styled-content> was reduced (95% confidence interval<\/jats:styled-content>); T\u2010score \u22121.34 (\u22121.55 to \u22121.13; P<\/jats:italic><.001) at the lumbar spine and \u22120.3 (\u22120.49 to \u22120.12; P<\/jats:italic>=.001) at the hip. There was no relationship between age of gonadectomy and BMD<\/jats:styled-content>. Thirty\u2010two subjects had BMD<\/jats:styled-content> measured before or within 2\u00a0years of gonadectomy, and mean BMD<\/jats:styled-content> was reduced (95% CI<\/jats:styled-content>) at the lumbar spine; T\u2010score: \u22121.05 (\u22121.54 to \u22120.57; P<\/jats:italic><.001), but was normal at the hip; T\u2010score \u22120.04 (\u22120.35 to 0.28; P<\/jats:italic>=.8). There was no relationship between BMD<\/jats:styled-content> and history of hernia, testosterone, oestradiol or follicle stimulating hormone levels. Twelve subjects had DXA<\/jats:styled-content> both before and after gonadectomy, and after 4.3 (1.7\u201012.8) years, there was no change in BMD<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>We found reduced BMD<\/jats:styled-content> at the spine and hip in subjects with CAIS<\/jats:styled-content>. We found no relationship between age of gonadectomy and BMD<\/jats:styled-content>, and we also found no drop in BMD<\/jats:styled-content> in subjects followed up after gonadectomy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13368","type":"journal-article","created":{"date-parts":[[2017,5,10]],"date-time":"2017-05-10T20:32:46Z","timestamp":1494448366000},"page":"136-140","source":"Crossref","is-referenced-by-count":32,"title":["Bone mineral density in complete androgen insensitivity syndrome and the timing of gonadectomy"],"prefix":"10.1111","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0383-3433","authenticated-orcid":false,"given":"Thomas F. J.","family":"King","sequence":"first","affiliation":[{"name":"Institute for Women's Health University College London Hospitals London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winnie Z. 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