{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T15:59:33Z","timestamp":1789747173460,"version":"4.0.1"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,6,19]],"date-time":"2017-06-19T00:00:00Z","timestamp":1497830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Context<\/jats:title><jats:p>Tasmania is an island state of the Australian Commonwealth with a well\u2010documented history of mild iodine deficiency. Between 2001 and 2009, Tasmania experienced two incremental phases of iodine fortification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine trends in thyroid\u2010stimulating hormone (<jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content>) and thyroid peroxidase antibody (<jats:styled-content style=\"fixed-case\">ATPO<\/jats:styled-content>) testing and their relationship to different phases of iodine nutrition in the Tasmanian population between 1995 and 2013.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective longitudinal study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting and participants<\/jats:title><jats:p>The major primary care and largest public hospital pathology providers in Tasmania submitted data for all <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ATPO<\/jats:styled-content> tests performed between 1995 and 2013. Data linkage methodology was used to determine trends in <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ATPO<\/jats:styled-content> testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1.66\u00a0million <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content> assessments, involving 389,910 individual patients, were performed in Tasmania between 1995 and 2013. There was approximately a fourfold increase in the overall rate of <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content> testing during this period with the rate of incident <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content> assessment remaining relatively stable over the study period. The incidence of overt suppression and elevation of <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content>\u22640.1\u00a0m<jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>\/L and \u226510\u00a0m<jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>\/L) declined 62.3% and 59.7%, respectively, with a trend for increased incidence of borderline <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content> elevation \u22654.0\u00a0m<jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>\/L. The incidence of thyroid autoimmunity as determined by the proportion of abnormal <jats:styled-content style=\"fixed-case\">ATPO<\/jats:styled-content> results remained stable, with the absolute number of positive test results increasing during the study period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Iodine supplementation of this mildly iodine\u2010deficient population was not associated with an obvious increase in incidence of overt thyroid dysfunction or autoimmunity. Whilst the volume of <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content> testing increased over the study period, the increase was driven by patients undergoing follow\u2010up <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content> assessments.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13371","type":"journal-article","created":{"date-parts":[[2017,5,13]],"date-time":"2017-05-13T08:57:14Z","timestamp":1494665834000},"page":"386-393","source":"Crossref","is-referenced-by-count":24,"title":["Temporal trends in thyroid\u2010stimulating hormone (<scp>TSH<\/scp>) and thyroid peroxidase antibody (<scp>ATPO<\/scp>) testing across two phases of iodine fortification in Tasmania (1995\u20102013)"],"prefix":"10.1111","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6307-0661","authenticated-orcid":false,"given":"A.","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Diabetes &amp; Endocrinology Royal Hobart Hospital  Hobart Tasmania"},{"name":"School of Medicine University of Tasmania  Hobart Tasmania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Stokes","sequence":"additional","affiliation":[{"name":"Menzies Institute for Medical Research University of Tasmania  Hobart Tasmania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Otahal","sequence":"additional","affiliation":[{"name":"Menzies Institute for Medical Research University of Tasmania  Hobart Tasmania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Owens","sequence":"additional","affiliation":[{"name":"School of Medicine University of Tasmania  Hobart Tasmania"},{"name":"Diagnostic Services Pty Ltd  Hobart Tasmania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.R.","family":"Burgess","sequence":"additional","affiliation":[{"name":"Department of Diabetes &amp; Endocrinology Royal Hobart Hospital  Hobart Tasmania"},{"name":"School of Medicine University of Tasmania  Hobart Tasmania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-2409"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.2.8182"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2016.0353"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja16.00545"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2009.02156.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.7326\/M14-1456"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.2.228"},{"key":"e_1_2_7_9_1","first-page":"143","article-title":"Variability in thyroid function test requests across general practices in south\u2010west England","volume":"21","author":"Vaidya B","year":"2013","journal-title":"Qual Prim Care"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2016.5381"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e3502"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(14)70225-6"},{"key":"e_1_2_7_13_1","first-page":"electronic text","volume-title":"The Iodine Deficiency Disorders","author":"Eastman CJ","year":"2000"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2014.01.001"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1430485"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-020750"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-13-0589"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2011.04008.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0613"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-2960"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.6.8600"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1971.tb92387.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.6006.372"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-0652"},{"key":"e_1_2_7_25_1","volume-title":"Year Book Australia 2012","author":"Pink BN","year":"2012"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2007.tb00803.x"},{"key":"e_1_2_7_27_1","unstructured":"Australian Bureau of Statistics.2013.http:\/\/www.abs.gov.au\/ausstats\/abs@.nsf\/Lookup\/4364.0.55.006Chapter1202011-12. 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