{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T11:22:07Z","timestamp":1789730527618,"version":"4.0.1"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,7,13]],"date-time":"2017-07-13T00:00:00Z","timestamp":1499904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Liaoning BaiQianWan Talents Program","award":["2014921033"],"award-info":[{"award-number":["2014921033"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2017,11]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>The rate of recurrent laryngeal nerve (RLN<\/jats:styled-content>) palsy, a common complication of thyroid surgery, is especially high in thyroid reoperations. The present meta\u2010analysis assesses whether intraoperative neuromonitoring (IONM<\/jats:styled-content>) reduces the prevalence of RLN<\/jats:styled-content> palsy in thyroid reoperations.<\/jats:p><\/jats:sec>Design and methods<\/jats:title>A systematic literature search was conducted in the PubMed, SCIE<\/jats:styled-content> and Wan Fang databases for studies published up to 31 August 2016. All data were analysed using STATA<\/jats:styled-content> (version 11) software. Publication bias was assessed using Begg's funnel plot and Egger's test, and sensitivity analysis was performed.<\/jats:p><\/jats:sec>Results<\/jats:title>Nine studies including 2436 at\u2010risk nerves met the inclusion criteria. The results were presented as pooled relative risks (RR<\/jats:styled-content>s) with 95% confidence intervals (CI<\/jats:styled-content>). The overall RLN<\/jats:styled-content> palsy rate was significantly lower in reoperations conducted with IONM<\/jats:styled-content> than in those conducted without IONM<\/jats:styled-content> (RR<\/jats:styled-content>=0.434, 95% CI<\/jats:styled-content>=0.206\u20100.916, P<\/jats:italic>=.029). High heterogeneity was found (I2<\/jats:sup>=70.2%, P<\/jats:italic>=.001). The rates of transient RLN<\/jats:styled-content> palsy with and without IONM<\/jats:styled-content> did not differ significantly (RR<\/jats:styled-content>=0.607, 95% CI<\/jats:styled-content>=0.270\u20101.366, P<\/jats:italic>=.227). The heterogeneity was high (I2<\/jats:sup>=67.4%, P<\/jats:italic>=.005). However, IONM<\/jats:styled-content> was significantly associated with a reduction in permanent RLN<\/jats:styled-content> palsy (RR<\/jats:styled-content>=0.426, 95% CI<\/jats:styled-content>=0.196\u20100.925, P<\/jats:italic>=.031). No significant heterogeneity was found (I2<\/jats:sup>=13.7%, P<\/jats:italic>=.325). Funnel plots for overall and transient RLN<\/jats:styled-content> palsy showed a possible publication bias.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Intraoperative neuromonitoring (IONM<\/jats:styled-content>) is associated with a reduction in overall and permanent RLN<\/jats:styled-content> palsy in thyroid reoperations. However, given the limited sample size and heterogeneity in this meta\u2010analysis, further studies are required to confirm our preliminary findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13379","type":"journal-article","created":{"date-parts":[[2017,6,6]],"date-time":"2017-06-06T11:22:38Z","timestamp":1496748158000},"page":"572-580","source":"Crossref","is-referenced-by-count":49,"title":["A meta\u2010analysis of intraoperative neuromonitoring of recurrent laryngeal nerve palsy during thyroid reoperations"],"prefix":"10.1111","volume":"87","author":[{"given":"Wei","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Thyroid Surgery The First Hospital of China Medical University Shenyang Liaoning Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Thyroid Surgery The First Hospital of China Medical University Shenyang Liaoning Province 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