{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:11:42Z","timestamp":1790799102087,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,6,19]],"date-time":"2017-06-19T00:00:00Z","timestamp":1497830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background\/Objectives<\/jats:title><jats:p>Polycystic ovary syndrome (<jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>) is a heterogeneous disorder characterized by chronic anovulation, hyperandrogenism, polycystic ovary morphology (<jats:styled-content style=\"fixed-case\">PCOM<\/jats:styled-content>) and metabolic disturbances including insulin resistance and type 2 diabetes mellitus. Although insulin resistance could be associated with <jats:styled-content style=\"fixed-case\">PCOM<\/jats:styled-content>, recent studies have shown controversial results. The aim of this study was to determine the relationship between <jats:styled-content style=\"fixed-case\">PCOM<\/jats:styled-content> and insulin resistance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects\/Methods<\/jats:title><jats:p>This was a cross\u2010sectional clinical study. A total of 679 women with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> who were diagnosed using the National Institute of Child Health and Human Disease (<jats:styled-content style=\"fixed-case\">NICHD<\/jats:styled-content>) criteria and 272 control women were analysed. We measured fasting glucose and insulin levels, 75\u00a0g oral glucose tolerance test\u2010derived glucose and insulin levels, testosterone levels, ovarian volume and follicle number.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Polycystic ovary morphology was described in 543 women (80.0%) with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>. Women with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> had significantly higher 2\u00a0hours postload glucose, fasting and 2\u00a0hours postload insulin levels, ovarian volume, ovarian follicle numbers and lower insulin sensitivity compared with those of the controls (all <jats:italic>P<\/jats:italic>&lt;.01). In women with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>, ovarian volume and ovarian follicle number were negatively associated with the quantitative insulin sensitivity check index after adjusting for age, body mass index and total testosterone; however, this association was not observed in the controls. In the logistic regression analysis, increased ovarian follicle number was associated with decreased insulin sensitivity in women with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>, enlarged ovarian volume and follicle excess were associated with insulin resistance, and the number of ovarian follicles could be a predictor of insulin resistance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13380","type":"journal-article","created":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T21:36:00Z","timestamp":1495575360000},"page":"375-380","source":"Crossref","is-referenced-by-count":18,"title":["Polycystic ovary morphology is associated with insulin resistance in women with polycystic ovary syndrome"],"prefix":"10.1111","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5194-8924","authenticated-orcid":false,"given":"So\u2010hyeon","family":"Hong","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism Department of Internal Medicine Ewha Womans University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeon\u2010Ah","family":"Sung","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism Department of Internal Medicine Ewha Womans University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Sun","family":"Hong","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism Department of Internal Medicine Ewha Womans University College of Medicine  Seoul South 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Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dep399"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2003.10.004"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.10.043"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.07.1375"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2004.12.061"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0219"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.01.032"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/den015"},{"key":"e_1_2_6_10_1","first-page":"377","volume-title":"Polycystic Ovary Syndrome","author":"Zawadzki 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