{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T10:34:07Z","timestamp":1769596447070,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T00:00:00Z","timestamp":1497398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270856"],"award-info":[{"award-number":["81270856"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The data on patients with short\u2010term remission of Cushing's disease (<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>) might provide information that is not available from previous long\u2010term remission studies. We aimed to investigate structural changes in the brain in these patients and to examine whether these changes were associated with clinical characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A cross\u2010sectional study was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010four patients with <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> (14 with <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> in short\u2010term remission and 20 with active <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>) and 34 controls matched for age, sex and education underwent clinical evaluation and magnetic resonance imaging brain scans. Biometric measurements, disease duration and remission duration data were collected. Grey matter volumes in the whole brain were examined using voxel\u2010based morphometry (<jats:styled-content style=\"fixed-case\">VBM<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No differences were observed in the grey matter volumes of the medial frontal gyrus (<jats:styled-content style=\"fixed-case\">MFG<\/jats:styled-content>) and cerebellum between the patients with remitted <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> and healthy controls, whereas patients with active <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> had smaller grey matter volumes in these two regions compared with controls and patients with remitted <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>. Furthermore, significant correlations were found between remission time and grey matter values in these regions in short\u2010term remission patients with <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>. Additionally, greater grey matter volumes in the bilateral caudate of short\u2010term remission patients with <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Trends for structural restoration were found in <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> patients with short\u2010term remission. This finding was associated with the number of days elapsed since curative surgery and the current age of the patients. This study enhances our understanding of potential reversibility after the resolution of hypercortisolism in <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13381","type":"journal-article","created":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T21:43:40Z","timestamp":1495575820000},"page":"367-374","source":"Crossref","is-referenced-by-count":26,"title":["Volumetric magnetic resonance imaging analysis in patients with short\u2010term remission of Cushing's disease"],"prefix":"10.1111","volume":"87","author":[{"given":"Hong","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Rui\u2010Jin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Rui\u2010Jin Hospital Shanghai Jiao Tong University 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