{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T04:26:24Z","timestamp":1785903984823,"version":"3.56.0"},"reference-count":76,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,6,30]],"date-time":"2017-06-30T00:00:00Z","timestamp":1498780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007427","name":"Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007427","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>A limited number of studies have evaluated the relationship between clinical and biochemical hyperandrogenism (<jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content>). This study aimed to evaluate the association between biochemical hyperandrogenism parameters (<jats:styled-content style=\"fixed-case\">BHP<\/jats:styled-content>s) and Ferriman\u2010Gallwey (<jats:styled-content style=\"fixed-case\">FG<\/jats:styled-content>) score in patients with polycystic ovary syndrome (<jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched PubMed, Scopus, Google Scholar, ScienceDirect and Web of Sciences databases (2000\u20102015) to identify studies investigating clinical and biochemical parameters of <jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> patients. In this meta\u2010analysis, both fixed and random effect models were applied to estimate pooled effect size. To assess the relationships between <jats:styled-content style=\"fixed-case\">BHP<\/jats:styled-content>s and <jats:styled-content style=\"fixed-case\">FG<\/jats:styled-content> score, meta\u2010regression analysis was used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010five study groups with a total of 6593 <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> patients were analysed. Meta\u2010regression analysis of pooled data from all eligible studies showed significant positive relationships of <jats:styled-content style=\"fixed-case\">FG<\/jats:styled-content> score with androstenedione (A4) (<jats:italic>P<\/jats:italic>=.034) and dehydroepiandrosterone sulphate (<jats:styled-content style=\"fixed-case\">DHEAS<\/jats:styled-content>) (<jats:italic>P<\/jats:italic>=.012), whereas it showed no association with total testosterone (<jats:styled-content style=\"fixed-case\">tT<\/jats:styled-content>), free testosterone (<jats:styled-content style=\"fixed-case\">fT<\/jats:styled-content>), sex hormone bonding globulin (<jats:styled-content style=\"fixed-case\">SHBG<\/jats:styled-content>) and free androgen index (<jats:styled-content style=\"fixed-case\">FAI<\/jats:styled-content>). The results did not change after adjusting for quality assessment or method of assay. Nor did the associations between A4 and <jats:styled-content style=\"fixed-case\">FG<\/jats:styled-content> score remain after adjusting for age and <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>, diagnostic criteria for <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> and study design or the association between <jats:styled-content style=\"fixed-case\">DHEAS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FG<\/jats:styled-content> score remain after adjusting for ethnicity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This meta\u2010analysis confirmed the associations of some <jats:styled-content style=\"fixed-case\">BHP<\/jats:styled-content>s, including A4 and <jats:styled-content style=\"fixed-case\">DHEAS<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">FG<\/jats:styled-content> score, indicating that measurement of these parameters can be useful for managing <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> patients with hirsutism.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13389","type":"journal-article","created":{"date-parts":[[2017,6,2]],"date-time":"2017-06-02T16:02:36Z","timestamp":1496419356000},"page":"217-230","source":"Crossref","is-referenced-by-count":51,"title":["Association between biochemical hyperandrogenism parameters and Ferriman\u2010Gallwey score in patients with polycystic ovary syndrome: A systematic review and meta\u2010regression analysis"],"prefix":"10.1111","volume":"87","author":[{"given":"Mina","family":"Amiri","sequence":"first","affiliation":[{"name":"Student Research Committee, Department of Midwifery and Reproductive Health, Faculty of Nursing and Midwifery Shahid Beheshti University of Medical Sciences  Tehran Iran"},{"name":"Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Sciences  Tehran 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