{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T23:21:50Z","timestamp":1773271310712,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T00:00:00Z","timestamp":1501200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400777"],"award-info":[{"award-number":["81400777"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1508219"],"award-info":[{"award-number":["U1508219"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570708"],"award-info":[{"award-number":["81570708"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>TNF<\/jats:styled-content>\u2010like weak inducer of apoptosis (TWEAK<\/jats:styled-content>), its receptor fibroblast growth factor\u2010inducible 14 (Fn14) and its scavenger receptor CD<\/jats:styled-content>163 (sCD<\/jats:styled-content>163) have known associations with many autoimmune diseases. However, the role of the TWEAK<\/jats:styled-content> axis in autoimmune thyroid disease (AITD<\/jats:styled-content>) remains unclear. Therefore, the aim of this study was to investigate the role of the TWEAK<\/jats:styled-content>\u2010Fn14 axis in the pathogenesis of AITD<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Serum levels of soluble TWEAK<\/jats:styled-content> (sTWEAK<\/jats:styled-content>) and sCD<\/jats:styled-content>163 were measured in 38 patients with Graves\u2019 disease (GD<\/jats:styled-content>), 40 patients with Hashimoto's thyroiditis (HT<\/jats:styled-content>) and 40 healthy controls (HC<\/jats:styled-content>s). Additionally, the mRNA<\/jats:styled-content> expression of TWEAK<\/jats:styled-content> and Fn14 in peripheral blood mononuclear cells (PBMC<\/jats:styled-content>s) was explored, and the protein expression of TWEAK<\/jats:styled-content> and Fn14 in thyroid glands surgically removed from 10 patients with GD<\/jats:styled-content>, 10 patients with HT<\/jats:styled-content> and 10 HC<\/jats:styled-content>s was studied by immunohistochemical staining.<\/jats:p><\/jats:sec>Results<\/jats:title>The results showed that the serum levels of sTWEAK<\/jats:styled-content> were significantly reduced in patients with HT<\/jats:styled-content> and inversely correlated with antithyroid peroxidase antibody (TPOA<\/jats:styled-content>b) levels. Additionally, high levels of sCD<\/jats:styled-content>163 and a high sCD<\/jats:styled-content>163\/sTWEAK<\/jats:styled-content> ratio were positively associated with the TPOA<\/jats:styled-content>b levels in patients with HT<\/jats:styled-content> and the thyrotropin receptor antibody (TRA<\/jats:styled-content>b) levels in patients with GD<\/jats:styled-content>. TWEAK mRNA<\/jats:styled-content> expression and protein expression were upregulated in thyroid glands and PBMC<\/jats:styled-content>s from patients with HT.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Expression of the TWEAK<\/jats:styled-content>\u2010Fn14 axis was upregulated in patients with AITD<\/jats:styled-content> and might play a role in the pathogenesis of AITD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13404","type":"journal-article","created":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T16:12:46Z","timestamp":1498061566000},"page":"783-790","source":"Crossref","is-referenced-by-count":7,"title":["Role of the tumour necrosis factor\u2010like weak inducer of apoptosis (TWEAK<\/scp>)\/fibroblast growth factor\u2010inducible 14 (Fn14) axis in autoimmune thyroid disease"],"prefix":"10.1111","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2164-2825","authenticated-orcid":false,"given":"Shiqiao","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism Institute of Endocrinology Liaoning Provincial Key Laboratory of Endocrine Diseases The First Affiliated Hospital of China Medical University China Medical University Shenyang Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohui","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Institute of Endocrinology Liaoning Provincial Key Laboratory of Endocrine Diseases The First Affiliated Hospital of China Medical University China Medical University Shenyang Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuemin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Institute of Endocrinology Liaoning Provincial Key Laboratory of Endocrine Diseases The First Affiliated Hospital of China Medical University China Medical University Shenyang Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Institute of Endocrinology Liaoning Provincial Key Laboratory of Endocrine Diseases The First Affiliated Hospital of China Medical University China Medical University Shenyang Liaoning China"},{"name":"Department of Laboratory Medicine The First Affiliated Hospital of China Medical University China Medical University Shenyang Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuren","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital of China Medical University China Medical University Shenyang Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Institute of Endocrinology Liaoning Provincial Key Laboratory of Endocrine Diseases The First Affiliated Hospital of China Medical University China Medical University Shenyang Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongyan","family":"Shan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Institute of Endocrinology Liaoning Provincial Key Laboratory of Endocrine Diseases The First Affiliated Hospital of China Medical University China Medical University Shenyang Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenyan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Institute of Endocrinology Liaoning Provincial Key Laboratory of Endocrine Diseases The First Affiliated Hospital of China Medical University China Medical University Shenyang Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiping","family":"Teng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Institute of Endocrinology Liaoning Provincial Key Laboratory of Endocrine Diseases The First Affiliated Hospital of China Medical University China Medical University Shenyang Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e3280113d1a"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/08916930410001705394"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2004.02085.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2016.02.011"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-015-8761-y"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.09.022"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00232-1"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.13.8455"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043919"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2007.10.022"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-6612-4_32"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00489"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2011.01054.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2488"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.131979"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2007.09.007"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2013.06.008"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2010.11.012"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3294"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0608347"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.12.8183"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/35051594"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2006.04.032"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.09.016"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.5603\/FHC.2011.0052"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1989.tb00864.x"},{"key":"e_1_2_8_28_1","first-page":"295","article-title":"A monoclonal antibody to a novel differentiation antigen on human macrophages associated with the down\u2010regulatory phase of the inflammatory process","volume":"55","author":"Zwadlo G","year":"1987","journal-title":"Exp Cell Biol"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00578"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-4177"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.5603\/EP.a2016.0033"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1719"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.67.1.97"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms141223893"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar4246"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00473"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcen.13404","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.13404","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T06:13:00Z","timestamp":1695535980000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.13404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,28]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1111\/cen.13404"],"URL":"https:\/\/doi.org\/10.1111\/cen.13404","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,28]]}}}