{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:46:42Z","timestamp":1787014002926,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,8,9]],"date-time":"2017-08-09T00:00:00Z","timestamp":1502236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007613","name":"Ankara Universitesi","doi-asserted-by":"publisher","award":["5000 Turkish Lira"],"award-info":[{"award-number":["5000 Turkish Lira"]}],"id":[{"id":"10.13039\/100007613","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2017,11]]},"abstract":"Summary<\/jats:title>\n \n Objective<\/jats:title>\n \n Symptomatic primary hyperparathyroidism (\n PHPT<\/jats:styled-content>\n ) is thought to be related to increased cardiovascular morbidity and mortality. In our study, we aimed to investigate endothelial dysfunction and markers of subclinical atherosclerosis in patients with\n PHPT<\/jats:styled-content>\n . Also we aimed to demonstrate the effect of vitamin D supplementation on these parameters.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and methods<\/jats:title>\n \n Twenty\u2010nine patients followed by medical treatment (A), 25 preoperative (B) and 23 postoperative patients with\n PHPT<\/jats:styled-content>\n (C), and 26 normocalcaemic subjects (D) were included. Groups were assessed by measurements of flow\u2010mediated dilation (\n FMD<\/jats:styled-content>\n ), carotid intima\u2010media thickness (\n CIMT<\/jats:styled-content>\n ), serum levels of\n sCD<\/jats:styled-content>\n 40L, high\u2010sensitivity\n CRP<\/jats:styled-content>\n (hs\u2010\n CRP<\/jats:styled-content>\n ) and interleukin\u20108 (\n IL<\/jats:styled-content>\n \u20108). Thirteen patients with low levels of 25\u2010hydroxy\u2010vitamin D (25\n OHD<\/jats:styled-content>\n ) in the medical treatment group were assessed before and 3\u00a0months after vitamin D replacement.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The median\n FMD<\/jats:styled-content>\n was 5% in group A, 5.1% in group B, 7.6% in group C and 7.7% in group D. The\n FMD<\/jats:styled-content>\n measurement in group A was significantly lower than groups C and D (\n P<\/jats:italic>\n =.02) and was similar to the\n FMD<\/jats:styled-content>\n measurement in group B.\n FMD<\/jats:styled-content>\n measurements of group B were not significantly lower than groups C and D. In 13 patients with low 25\n OHD<\/jats:styled-content>\n in group A, the median\n FMD<\/jats:styled-content>\n increased to 7.07% from 4.71% after vitamin D replacement (\n P<\/jats:italic>\n =.02).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Flow\u2010mediated dilation was impaired in patients with\n PHPT<\/jats:styled-content>\n , particularly in the medically observed group. Vitamin D supplementation seems to provide improvements in\n FMD<\/jats:styled-content>\n in medically observed\n PHPT<\/jats:styled-content>\n patients with low 25\n OHD<\/jats:styled-content>\n levels, and this was the novel observation of our study.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/cen.13418","type":"journal-article","created":{"date-parts":[[2017,7,7]],"date-time":"2017-07-07T10:07:38Z","timestamp":1499422058000},"page":"459-465","source":"Crossref","is-referenced-by-count":13,"title":["Is primary hyperparathyroidism a cause of endothelial dysfunction?"],"prefix":"10.1111","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9042-9668","authenticated-orcid":false,"given":"Sevgi","family":"Colak","sequence":"first","affiliation":[{"name":"Department of Internal Medicine University of Ankara \u0130bni Sina Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9806-3891","authenticated-orcid":false,"given":"Berna Imge","family":"Aydogan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism University of Ankara \u0130bni Sina Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asena","family":"Gokcay Canpolat","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism University of Ankara \u0130bni Sina Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cansin","family":"Tulunay Kaya","sequence":"additional","affiliation":[{"name":"Department of Cardiology University of Ankara \u0130bni Sina Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Sahin","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism University of Ankara \u0130bni Sina Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demet","family":"Corapcioglu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism University of Ankara \u0130bni Sina Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Riza","family":"Uysal","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism University of Ankara \u0130bni Sina Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rifat","family":"Emral","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism University of Ankara \u0130bni Sina Hospital Ankara 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