{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:19:41Z","timestamp":1762867181669,"version":"3.37.3"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,8,8]],"date-time":"2017-08-08T00:00:00Z","timestamp":1502150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Context<\/jats:title><jats:p>McCune\u2010Albright syndrome (<jats:styled-content style=\"fixed-case\">MAS<\/jats:styled-content>) is associated with numerous health problems. Comprehensive long\u2010term health problems of adults with <jats:styled-content style=\"fixed-case\">MAS<\/jats:styled-content> are less well defined in the literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Our objective is to report comprehensive health outcomes of adults with <jats:styled-content style=\"fixed-case\">MAS<\/jats:styled-content> (&gt;18\u00a0years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective case note review of 16 adults with <jats:styled-content style=\"fixed-case\">MAS<\/jats:styled-content> managed by one clinician. Results expressed as median (range).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 16 adults (seven males) with <jats:styled-content style=\"fixed-case\">MAS<\/jats:styled-content>. Median current age is 29\u00a0years (20, 46). Twelve of 16 had craniofacial fibrous dysplasia with five of 12 (42%) with progressive facial asymmetry. Growth hormone excess was observed in six of 16 (38%) and T3\u2010toxicosis in five of 16 (31.3%). Six of the seven men (86%) had abnormalities on testicular ultrasound with one man exhibiting marked atrophy of germ and sertoli cells with reduction in spermatogenesis. Six of the 16 (38%) had cardiorespiratory complications including high output cardiac failure (n,3), hypertension (n,2) and one man with congestive cardiac failure and restrictive lung disease. Six of eight (66%) who had screening endoscopy for upper gastrointestinal polyps show increasing numbers of polyps, with benign histology to date. One woman with a previous history of early puberty presented with early aggressive breast carcinoma, which was positive for <jats:styled-content style=\"fixed-case\">GNAS<\/jats:styled-content>. Two patients had <jats:styled-content style=\"fixed-case\">GNAS<\/jats:styled-content>\u2010positive muscle myomas. Platelet dysfunction with bleeding tendency responsive to platelet transfusion during surgery was seen in four.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A range of complex health problems is encountered in adults with <jats:styled-content style=\"fixed-case\">MAS<\/jats:styled-content>. These have important implications for transition of patients with <jats:styled-content style=\"fixed-case\">MAS<\/jats:styled-content> and adult care. Long\u2010term cancer risk is currently unknown but requires careful follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13419","type":"journal-article","created":{"date-parts":[[2017,7,12]],"date-time":"2017-07-12T05:16:41Z","timestamp":1499836601000},"page":"627-634","source":"Crossref","is-referenced-by-count":11,"title":["Long\u2010term health outcomes of adults with McCune\u2010Albright syndrome"],"prefix":"10.1111","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2845-6555","authenticated-orcid":false,"given":"Sze Choong","family":"Wong","sequence":"first","affiliation":[{"name":"Developmental Endocrinology Research Group Royal Hospital for Children  Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"Zacharin","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The Royal Children's Hospital  Melbourne VIC Australia"},{"name":"Centre for Hormone Research Murdoch Children's Research Institute  Melbourne VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2005.18.1.33"},{"issue":"4","key":"e_1_2_9_3_1","first-page":"412","article-title":"The spectrum of McCune Albright syndrome","volume":"4","author":"Zacharin M","year":"2007","journal-title":"Pediatr Endocrinol Rev"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"2980","DOI":"10.1001\/jama.1986.03380210076028","article-title":"McCune\u2010Albright syndrome. 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