{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T13:21:56Z","timestamp":1793971316871,"version":"4.8.0"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T00:00:00Z","timestamp":1502928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The outcomes of patients with metastatic phaeochromocytoma (PHEO) and paraganglioma (PGL) are unclear. We performed a systematic review and meta\u2010analysis of baseline characteristics and mortality rates of patients with metastatic PHEO and PGL (PPGL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Ovid MEDLINE In\u2010Process &amp; Other Non\u2010Indexed Citations, Ovid MEDLINE, Ovid EMBASE, Ovid Cochrane Central Register of Controlled Trials, Ovid Cochrane Database of Systematic Reviews, Scopus, Web of Science, and references of key articles were searched from inception to 2016.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>Studies comprised \u226520 patients with metastatic PPGL and reported baseline characteristics and follow\u2010up data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>Reviewers extracted standardized data and assessed risk of bias using a modified Newcastle\u2010Ottawa tool. Random\u2010effects meta\u2010analysis was used to pool event rates across studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty retrospective noncomparative studies reported on 1338 patients with metastatic PHEO (685\/1296, 52.9%) and PGL (611\/1296, 47.1%), diagnosed at a mean age of 43.9\u00a0\u00b1\u00a05.2\u00a0years. Mean follow\u2010up was 6.3\u00a0\u00b1\u00a03.2\u00a0years. Of 532 patients with reported data, 40.4% had synchronous metastases. Five\u2010year (7 studies, n\u00a0=\u00a0738) and 10\u2010year (2 studies, n\u00a0=\u00a055) mortality rates for patients with metastatic PPGL were 37% (95% CI, 24%\u201051%) and 29% (95% CI, 17%\u201042%), respectively. Higher mortality was associated with male sex (RR 1.50; 95% CI, 1.11\u20102.02) and synchronous metastases (RR 2.43; 95% CI, 1.01\u20105.85).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Available low\u2010quality evidence from heterogeneous studies suggests low mortality rates of patients with metastatic PPGL. Male sex and synchronous metastases correlated with increased mortality. The outcomes of patients with metastatic PPGL have been inadequately assessed, indicating the need for carefully planned prospective studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.13434","type":"journal-article","created":{"date-parts":[[2017,7,26]],"date-time":"2017-07-26T16:16:42Z","timestamp":1501085802000},"page":"440-450","source":"Crossref","is-referenced-by-count":110,"title":["Outcomes of patients with metastatic phaeochromocytoma and paraganglioma: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7367-3885","authenticated-orcid":false,"given":"Oksana","family":"Hamidi","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Nutrition Mayo Clinic  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"William F.","family":"Young","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Nutrition Mayo Clinic  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucinda","family":"Gruber","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Mayo Clinic  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Smestad","sequence":"additional","affiliation":[{"name":"Mayo Clinic Medical Scientist Training Program Mayo Clinic  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Surgery Mayo Clinic  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar J.","family":"Ponce","sequence":"additional","affiliation":[{"name":"Evidence\u2010based Practice Center Mayo Clinic  Rochester MN USA"},{"name":"Unidad de Conocimiento y Evidencia Universidad Peruana Cayetano Heredia  Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry","family":"Prokop","sequence":"additional","affiliation":[{"name":"Evidence\u2010based Practice Center Mayo Clinic  Rochester MN USA"},{"name":"Mayo Clinic Libraries Mayo Clinic  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Hassan","family":"Murad","sequence":"additional","affiliation":[{"name":"Evidence\u2010based Practice Center Mayo Clinic  Rochester MN USA"},{"name":"Division of Preventive Medicine Mayo Clinic  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Bancos","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Nutrition Mayo Clinic  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.1484"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-013-0320-x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000345671"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1301302"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1991.244"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.29.5.1133"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199906000-00001"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1758-3284-2-23"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23297"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10252"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-011-0880-x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-1946"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2535"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90046-2"},{"key":"e_1_2_8_16_1","article-title":"Pathology and Genetics of Tumours of Endocrine Organs. 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