{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:33:07Z","timestamp":1791995587556,"version":"4.4.0"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,10,4]],"date-time":"2017-10-04T00:00:00Z","timestamp":1507075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Asan institue for Life Sciences","award":["No. 2017-749"],"award-info":[{"award-number":["No. 2017-749"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2018,1]]},"abstract":"Summary<\/jats:title>Objective<\/jats:title>Previous studies did not focus on the differences in the extent of cervical lymph node (LN<\/jats:styled-content>) dissection according to coexistent Hashimoto's thyroiditis (HT<\/jats:styled-content>) in patients with papillary thyroid carcinoma (PTC<\/jats:styled-content>) and its clinical impact. We aimed to determine whether extensive cervical LN<\/jats:styled-content> dissection is responsible for favourable clinical outcomes in PTC<\/jats:styled-content> patients with HT<\/jats:styled-content> and whether the coexistence of HT<\/jats:styled-content> itself has an independent protective effect regardless of LN<\/jats:styled-content> status.<\/jats:p><\/jats:sec>Design<\/jats:title>Retrospective cohort study.<\/jats:p><\/jats:sec>Patients<\/jats:title>1369 patients with PTC<\/jats:styled-content> who underwent total thyroidectomy with central compartment neck dissection.<\/jats:p><\/jats:sec>Measurements<\/jats:title>Metastatic LN<\/jats:styled-content> ratio, defined as number of metastatic LN<\/jats:styled-content>s divided by number of removed LN<\/jats:styled-content>s, was used to evaluate the extent of LN<\/jats:styled-content> dissection as well as the status of LN<\/jats:styled-content> metastasis. Disease\u2010free survival and dynamic risk stratification were compared for clinical outcomes.<\/jats:p><\/jats:sec>Results<\/jats:title>Presence of HT<\/jats:styled-content> did not lower the risk of cervical LN<\/jats:styled-content> metastasis (61.6% in patients with HT <\/jats:styled-content>vs<\/jats:italic> 65.1% in patients without HT<\/jats:styled-content>, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.292). Patients with HT<\/jats:styled-content> had significantly larger numbers of removed LN<\/jats:styled-content>s than patients without HT<\/jats:styled-content> (11 vs<\/jats:italic> 8, respectively, P\u00a0<\/jats:italic><\u00a0<\/jats:italic>.001). Accordingly, metastatic LN<\/jats:styled-content> ratio was smaller in patients with HT<\/jats:styled-content> (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.002), which was independently associated with structural persistent\/recurrent disease (hazard ratio [HR<\/jats:styled-content>] 2.33, 95% confidence interval [CI<\/jats:styled-content>] 1.30\u20104.16, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.004). HT<\/jats:styled-content> itself was negatively associated with structural persistent\/recurrent disease after adjustment for other clinicopathological factors (HR<\/jats:styled-content> 0.39, 95% CI<\/jats:styled-content> 0.18\u20100.87, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.020).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Coexistence of HT<\/jats:styled-content> itself is an independent factor associated with favourable outcome in PTC<\/jats:styled-content> patients, regardless of the extent of LN<\/jats:styled-content> dissection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13475","type":"journal-article","created":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T10:56:41Z","timestamp":1505386601000},"page":"123-128","source":"Crossref","is-referenced-by-count":49,"title":["Influence of coexistent Hashimoto's thyroiditis on the extent of cervical lymph node dissection and prognosis in papillary thyroid carcinoma"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6034-0758","authenticated-orcid":false,"given":"Eyun","family":"Song","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1297-107X","authenticated-orcid":false,"given":"Min Ji","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suyeon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1538-8859","authenticated-orcid":false,"given":"Mijin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye\u2010Seon","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Eun","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pathology Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8404-7759","authenticated-orcid":false,"given":"Won Gu","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Bae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Kee","family":"Shong","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4982-4441","authenticated-orcid":false,"given":"Tae Yong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1955.01270080137023"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2007.09.020"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-2978"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-1309"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.1998.8.197"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-011-9164-9"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2009.03537.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002674"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21518"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.4158\/E151078.OR"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-88441-7"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-13-0524"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-4534-4"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1740-2557-2-1"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.84.2.5443"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(96)90346-9"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5302.960"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2008.0144"}],"container-title":["Clinical 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