{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T10:34:07Z","timestamp":1779273247004,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Little is known about the natural changes in parathyroid function after successful parathyroid surgery for primary hyperparathyroidism. The association of intact parathyroid hormone (<jats:styled-content style=\"fixed-case\">iPTH<\/jats:styled-content>) and calcium (Ca) with \u201ctemporary hypoparathyroidism\u201d and \u201chungry bone syndrome\u201d (<jats:styled-content style=\"fixed-case\">HBS<\/jats:styled-content>) was evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Potential risk factors for temporary hypoparathyroidism and <jats:styled-content style=\"fixed-case\">HBS<\/jats:styled-content> were evaluated by taking blood samples before surgery, intra\u2010operatively, at postoperative day (<jats:styled-content style=\"fixed-case\">POD<\/jats:styled-content>) 1, at <jats:styled-content style=\"fixed-case\">POD<\/jats:styled-content> 5 to 7, in postoperative week (<jats:styled-content style=\"fixed-case\">POW<\/jats:styled-content>) 8 and in postoperative month (<jats:styled-content style=\"fixed-case\">POM<\/jats:styled-content>) 6.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>Of 425 patients, 43 (10.1%) had temporary hypoparathyroidism and 36 (8.5%) had <jats:styled-content style=\"fixed-case\">HBS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>The discriminative ability of <jats:styled-content style=\"fixed-case\">iPTH<\/jats:styled-content> and Ca on <jats:styled-content style=\"fixed-case\">POD<\/jats:styled-content> 1 for temporary hypoparathyroidism and <jats:styled-content style=\"fixed-case\">HBS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Intact parathyroid hormone (IPTH) on <jats:styled-content style=\"fixed-case\">POD<\/jats:styled-content> 1 showed the highest discriminative ability for temporary hypoparathyroidism (C\u2010index\u00a0=\u00a00.952), but not for <jats:styled-content style=\"fixed-case\">HBS<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">IPTH<\/jats:styled-content> was helpful in diagnosing <jats:styled-content style=\"fixed-case\">HBS<\/jats:styled-content> between <jats:styled-content style=\"fixed-case\">POD<\/jats:styled-content> 5 and 7 (C\u2010index\u00a0=\u00a00.708). Extending the model by including Ca resulted in little improvement of the discriminative ability for temporary hypoparathyroidism (C\u2010index\u00a0=\u00a00.964) and a decreased discriminative ability for <jats:styled-content style=\"fixed-case\">HBS<\/jats:styled-content> (C\u2010index\u00a0=\u00a00.705). Normal parathyroid metabolism was documented in 139 (32.7%) patients on <jats:styled-content style=\"fixed-case\">POD<\/jats:styled-content> 1 and in 423 (99.5%) 6\u00a0months postoperatively, while 2 (0.5%) patients had persistent hyperparathyroidism, one diagnosed between <jats:styled-content style=\"fixed-case\">POD<\/jats:styled-content> 5 and 7 and another at <jats:styled-content style=\"fixed-case\">POW<\/jats:styled-content> 8. No patients suffered from permanent hypoparathyroidism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The necessity for Ca and vitamin D3 substitution cannot be predicted with certainty before <jats:styled-content style=\"fixed-case\">POD<\/jats:styled-content> 5 to 7 without serial laboratory measurements. Based on the results, a routine 8\u2010week course of Ca and vitamin D3 treatment seems reasonable and its necessity should be evaluated in a follow\u2010up study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13476","type":"journal-article","created":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T11:02:42Z","timestamp":1505386962000},"page":"129-138","source":"Crossref","is-referenced-by-count":18,"title":["Primary hyperparathyroidism: Dynamic postoperative metabolic changes"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8190-8771","authenticated-orcid":false,"given":"Reto M.","family":"Kaderli","sequence":"first","affiliation":[{"name":"Section of Endocrine Surgery Division of General Surgery Department of Surgery Medical University of Vienna Vienna Austria"},{"name":"Department of Visceral Surgery and Medicine, Inselspital Bern University Hospital, University of Bern Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Riss","sequence":"additional","affiliation":[{"name":"Section of Endocrine Surgery Division of General Surgery Department of Surgery Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelika","family":"Geroldinger","sequence":"additional","affiliation":[{"name":"Section for Clinical Biometrics Center for Medical Statistics, Informatics, and Intelligent Systems (CeMSIIS) Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Selberherr","sequence":"additional","affiliation":[{"name":"Section of Endocrine Surgery Division of General Surgery Department of Surgery Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Scheuba","sequence":"additional","affiliation":[{"name":"Section of Endocrine Surgery Division of General Surgery Department of Surgery Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Niederle","sequence":"additional","affiliation":[{"name":"Section of Endocrine Surgery Division of General Surgery Department of Surgery Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,10]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"The Parathyroids: Basic and Clinical Concepts","author":"Bilezikian JP","year":"2014"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2007.05.004"},{"issue":"4","key":"e_1_2_6_4_1","first-page":"S192","article-title":"Serum PTH and ionized calcium levels as predictors of symptomatic hypocalcemia after parathyroidectomy","volume":"120","author":"Zuberi KA","year":"2010","journal-title":"Laryngoscope"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1177\/000313480206801211","article-title":"Are preoperative serum calcium, parathyroid hormone, and adenoma weight predictive of postoperative hypocalcemia?","volume":"68","author":"Strickland PL","year":"2002","journal-title":"Am Surg"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1177\/000313480407000204","article-title":"Post\u2010parathyroidectomy hypocalcemia: incidence, risk factors, and management","volume":"70","author":"Mittendorf EA","year":"2004","journal-title":"Am Surg"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejs.6161681006"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surge.2012.12.002"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2011.09.018"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.132.1.41"},{"key":"e_1_2_6_11_1","first-page":"207","article-title":"Intraoperative parathormone measurements and postoperative hypocalcemia","volume":"12","author":"Stepansky A","year":"2010","journal-title":"Isr Med Assoc J"},{"key":"e_1_2_6_12_1","first-page":"16","article-title":"Utility of intraoperative parathyroid hormone measurement in predicting postparathyroidectomy hypocalcemia","volume":"37","author":"Shoman N","year":"2008","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800830433"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-12-0528"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-17-0416"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2014.09.007"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2016.2310"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1413"},{"key":"e_1_2_6_19_1","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1007\/s00423-016-1373-8","article-title":"Multigland primary hyperparathyroidism\u2013frequently considered, seldom encountered","volume":"400","author":"Mihai R","year":"2015","journal-title":"Langenbecks Arch Surg"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1072-7515(02)01897-5"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-4283-4"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365513.2017.1336568"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1047"},{"key":"e_1_2_6_24_1","first-page":"305","article-title":"Daily follow\u2010up of serum parathyroid hormone and calcium after surgery for primary hyperparathyroidism","volume":"28","author":"Debruyne F","year":"1999","journal-title":"J Otolaryngol"},{"key":"e_1_2_6_25_1","first-page":"153","article-title":"Postoperative course of serum parathyroid hormone and calcium after surgery for primary hyperparathyroidism","volume":"55","author":"Debruyne F","year":"2001","journal-title":"Acta Otorhinolaryngol Belg"},{"key":"e_1_2_6_26_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0002-9343(88)90100-3","article-title":"Hungry bone syndrome: clinical and biochemical predictors of its occurrence after parathyroid surgery","volume":"84","author":"Brasier AR","year":"1988","journal-title":"Am J Med"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(86)90436-8"},{"key":"e_1_2_6_28_1","first-page":"1","article-title":"Could we predict adenoma weight and postoperative serum calcium level with preoperative serum biochemical markers in patients with primary hyperparathyroidism?","volume":"16","author":"Nasiri S","year":"2007","journal-title":"Internet J Surg"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-009-0377-8"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2005.09.018"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03346273"},{"key":"e_1_2_6_32_1","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1177\/000313481207800347","article-title":"Predictive factors for postoperative severe hypocalcaemia after parathyroidectomy for primary hyperparathyroidism","volume":"78","author":"Crea N","year":"2012","journal-title":"Am Surg"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200211000-00001"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2010.03.019"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2004.06.053"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200312000-00029"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00104-014-2817-8"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcen.13476","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.13476","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T10:02:47Z","timestamp":1695981767000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.13476"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1111\/cen.13476"],"URL":"https:\/\/doi.org\/10.1111\/cen.13476","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10]]}}}