{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:00:24Z","timestamp":1783483224587,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T00:00:00Z","timestamp":1511136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To study the effect of a iodine load on thyroid function of patients with ischaemic heart disease (<jats:styled-content style=\"fixed-case\">IHD<\/jats:styled-content>) and the long\u2010term influence of unknown subclinical hyperthyroidism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Context<\/jats:title><jats:p>Subclinical hyperthyroidism is considered an independent risk factors for cardiovascular morbidity of patients with <jats:styled-content style=\"fixed-case\">IHD<\/jats:styled-content>. They routinely undergo coronary angiography with iodine contrast media (<jats:styled-content style=\"fixed-case\">ICM<\/jats:styled-content>) which may induce or even worsen hyperthyroidism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A cross\u2010sectional study followed by a longitudinal study on patients with subclinical hyperthyroidism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>810 consecutive <jats:styled-content style=\"fixed-case\">IHD<\/jats:styled-content> outpatients without known thyroid diseases or treatment with drugs influencing thyroid activity undergoing elective coronary angiography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>We evaluated thyroid function either before and 1\u00a0month after <jats:styled-content style=\"fixed-case\">ICM<\/jats:styled-content>; patients with thyrotoxicosis at baseline or after <jats:styled-content style=\"fixed-case\">ICM<\/jats:styled-content> were then followed up for 1\u00a0year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>58 patients had hyperthyroidism at baseline (<jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>, 7.2%), independently associated to <jats:styled-content style=\"fixed-case\">FT<\/jats:styled-content>4 levels, thyroid nodules and family history of thyroid diseases. After <jats:styled-content style=\"fixed-case\">ICM<\/jats:styled-content>, the prevalence of hyperthyroidism was 81 (10%). Hyperthyroidism after <jats:styled-content style=\"fixed-case\">ICM<\/jats:styled-content> was positively predicted by baseline <jats:styled-content style=\"fixed-case\">fT<\/jats:styled-content>4 levels, thyroid nodules, age over 60, male gender, family history of thyroid diseases. Three months after <jats:styled-content style=\"fixed-case\">ICM<\/jats:styled-content>, 34 patients (4.2%) still showed hyperthyroidism (22 from <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>, 13 treated with methimazole). One year after <jats:styled-content style=\"fixed-case\">ICM<\/jats:styled-content>, hyperthyroidism was still present in 20 patients (2.5%, all from <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>, 13 treated).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The prevalence of spontaneous subclinical hyperthyroidism in <jats:styled-content style=\"fixed-case\">IHD<\/jats:styled-content> is surprisingly elevated and is further increased by iodine load, particularly in patients with thyroid nodules and familial history of thyroid diseases, persisting in a not negligible number of them even after one year.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13494","type":"journal-article","created":{"date-parts":[[2017,10,12]],"date-time":"2017-10-12T07:22:35Z","timestamp":1507792955000},"page":"272-278","source":"Crossref","is-referenced-by-count":21,"title":["Hyperthyroidism in patients with ischaemic heart disease after iodine load induced by 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