{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:46:40Z","timestamp":1787014000501,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T00:00:00Z","timestamp":1511136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI081449"],"award-info":[{"award-number":["PI081449"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Type 1 and type 2 familial partial lipodystrophies (\n                      <jats:styled-content style=\"fixed-case\">FPLD<\/jats:styled-content>\n                      ) are characterized by the loss or increase in subcutaneous fat in certain body regions, as well as metabolic disorders. Higher muscle volume and mass have also been described. However, so far, possible bone involvement has not been studied. The aim of this study was to evaluate bone mineral density (\n                      <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>\n                      ) in patients with type 1 and type 2\n                      <jats:styled-content style=\"fixed-case\">FPLD<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 143 women were selected and distributed into three groups (17 women with\n                      <jats:styled-content style=\"fixed-case\">FPLD<\/jats:styled-content>\n                      2, 82 women with\n                      <jats:styled-content style=\"fixed-case\">FPLD<\/jats:styled-content>\n                      1 and 44 nonlipodystrophic obese female controls). A thorough history and physical examination were carried out on all subjects, as well as the measurement of anthropometric features.\n                      <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>\n                      along with fat and fat\u2010free mass (\n                      <jats:styled-content style=\"fixed-case\">FFM<\/jats:styled-content>\n                      ) were determined by\n                      <jats:styled-content style=\"fixed-case\">DXA<\/jats:styled-content>\n                      (dual\u2010energy X\u2010ray absorptiometry). Statistical analyses, primarily using the \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      , ANOVA and ANCOVA tests, were performed, using age, height, fat and\n                      <jats:styled-content style=\"fixed-case\">FFM<\/jats:styled-content>\n                      as covariables.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After eliminating the possible influences of age, height, fat and\n                      <jats:styled-content style=\"fixed-case\">FFM<\/jats:styled-content>\n                      , we observed that there were no significant differences in total\n                      <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>\n                      between patients with\n                      <jats:styled-content style=\"fixed-case\">FPLD<\/jats:styled-content>\n                      and the control group, showing total\n                      <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>\n                      values of 1.092\u00a0\u00b1\u00a00.037\u00a0g\/cm\n                      <jats:sup>2<\/jats:sup>\n                      in the\n                      <jats:styled-content style=\"fixed-case\">FPLD<\/jats:styled-content>\n                      2 group, 1.158\u00a0\u00b1\u00a00.013\u00a0g\/cm\n                      <jats:sup>2<\/jats:sup>\n                      in the\n                      <jats:styled-content style=\"fixed-case\">FPLD<\/jats:styled-content>\n                      1 group and 1.173\u00a0\u00b1\u00a00.018\u00a0g\/cm\n                      <jats:sup>2<\/jats:sup>\n                      in the control group (\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      .194). Similarly, no significant differences were found in segmental\n                      <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Unlike in other types of laminopathy in which bone is affected, in the case of\n                      <jats:styled-content style=\"fixed-case\">FPLD<\/jats:styled-content>\n                      , there are no differences in\n                      <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>\n                      compared to nonlipodystrophic subjects.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.13504","type":"journal-article","created":{"date-parts":[[2017,10,27]],"date-time":"2017-10-27T12:36:34Z","timestamp":1509107794000},"page":"44-50","source":"Crossref","is-referenced-by-count":13,"title":["Bone mineral density in familial partial lipodystrophy"],"prefix":"10.1111","volume":"88","author":[{"given":"Ant\u00eda","family":"Fern\u00e1ndez\u2010Pombo","sequence":"first","affiliation":[{"name":"UETeM\u2010Molecular Pathology Group Department of Medicine IDIS\u2010CIMUS University of Santiago de Compostela Santiago de Compostela Spain"},{"name":"Division of Endocrinology and Nutrition University Clinical Hospital of Santiago de Compostela Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier A.","family":"Ossandon\u2010Otero","sequence":"additional","affiliation":[{"name":"UETeM\u2010Molecular Pathology Group Department of Medicine IDIS\u2010CIMUS University of Santiago de Compostela Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Guill\u00edn\u2010Amarelle","sequence":"additional","affiliation":[{"name":"UETeM\u2010Molecular Pathology Group Department of Medicine IDIS\u2010CIMUS University of Santiago de Compostela Santiago de Compostela Spain"},{"name":"Division of Endocrinology and Nutrition University Clinical Hospital of Santiago de Compostela Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sof\u00eda","family":"S\u00e1nchez\u2010Iglesias","sequence":"additional","affiliation":[{"name":"UETeM\u2010Molecular Pathology Group Department of Medicine IDIS\u2010CIMUS University of Santiago de Compostela Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana I.","family":"Castro","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Nutrition University Clinical Hospital of Santiago de Compostela Santiago de Compostela Spain"},{"name":"CIBER Fisiopatolog\u00eda de la Obesidad y la Nutrici\u00f3n (CIBERobn) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanca","family":"Gonz\u00e1lez\u2010M\u00e9ndez","sequence":"additional","affiliation":[{"name":"UETeM\u2010Molecular Pathology Group Department of Medicine IDIS\u2010CIMUS University of Santiago de Compostela Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Rodr\u00edguez\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"UETeM\u2010Molecular Pathology Group Department of Medicine IDIS\u2010CIMUS University of Santiago de Compostela Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia","family":"Rodriguez\u2010Ca\u00f1ete","sequence":"additional","affiliation":[{"name":"UETeM\u2010Molecular Pathology Group Department of Medicine IDIS\u2010CIMUS University of Santiago de Compostela Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe F.","family":"Casanueva","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Nutrition University Clinical Hospital of Santiago de Compostela Santiago de Compostela Spain"},{"name":"CIBER Fisiopatolog\u00eda de la Obesidad y la Nutrici\u00f3n (CIBERobn) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2852-7851","authenticated-orcid":false,"given":"David","family":"Ara\u00fajo\u2010Vilar","sequence":"additional","affiliation":[{"name":"UETeM\u2010Molecular Pathology Group Department of Medicine IDIS\u2010CIMUS University of Santiago de Compostela Santiago de Compostela Spain"},{"name":"Division of Endocrinology and Nutrition University Clinical Hospital of Santiago de Compostela Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-2466"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-016-1002-x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3714"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.84.1.170"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00047.2005"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medcli.2014.02.024"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-38388"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.18.2225"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-2521"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.6.1819"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)00414-3"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31346"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1086\/341908"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200105250-00005"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4402197"},{"key":"e_1_2_8_17_1","volume-title":"Molecular Cloning: a Laboratory Manual","author":"Sambrook J","year":"1990"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.21.12.2191"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-1297"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.34249"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100090504"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.03-1100fje"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31983"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2010.06.004"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12657"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.081010"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.25185"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019313"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.49.11.1958"},{"key":"e_1_2_8_30_1","doi-asserted-by":"crossref","first-page":"E1493","DOI":"10.1210\/jc.2014-1353","article-title":"Bone mineral content in patients with congenital generalized lipodystrophy is unaffected by metreleptin replacement therapy","volume":"99","author":"Christensen JD","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/gls163"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.3232"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2407"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.2000.00234.x"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcen.13504","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.13504","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T06:03:35Z","timestamp":1695967415000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.13504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,20]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1111\/cen.13504"],"URL":"https:\/\/doi.org\/10.1111\/cen.13504","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,20]]}}}