{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T11:25:32Z","timestamp":1785583532849,"version":"3.56.0"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,11,24]],"date-time":"2017-11-24T00:00:00Z","timestamp":1511481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["N0.5\/9\/1112\/2013\u2010NUT"],"award-info":[{"award-number":["N0.5\/9\/1112\/2013\u2010NUT"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cholecalciferol and\/or calcium supplementation might increase skeletal muscle strength and serum testosterone in young adult males.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We performed a randomized control trial assessing the effect of cholecalciferol\/calcium on skeletal muscle strength and serum testosterone in vitamin D deficient young males.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Two\u2010by\u2010two factorial <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subject and Intervention<\/jats:title><jats:p>Two\u2010hundred and twenty\u2010eight young males were block\u2010randomized to (i) double\u2010placebo, (ii) calcium\/placebo, (iii) cholecalciferol\/placebo and (iv) cholecalciferol\/calcium. Doses for cholecalciferol were 60\u00a0000\u00a0<jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>\/wk for 8\u00a0weeks followed by 60\u00a0000\u00a0<jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>\/fortnightly, and doses for elemental calcium were 500 mg\/twice daily for 6\u00a0months. A total of 180 subjects completed the study protocol. Their \u00a0ean age, body mass index and baseline 25(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)D were 20.2\u00a0\u00b1\u00a02.2\u00a0years, 23.0\u00a0\u00b1\u00a03.6\u00a0kg\/m<jats:sup>2<\/jats:sup> and 21.5\u00a0\u00b1\u00a09.5\u00a0nmol\/L, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Handgrip (primary outcome), pinch\u2010grip strength, distance walked in 6\u00a0minutes, dyspnoea\u2010score, quality of life by Short Form 36, serum 25(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)D, 1,25(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)<jats:sub>2<\/jats:sub>D, <jats:styled-content style=\"fixed-case\">iPTH<\/jats:styled-content>, total testosterone and free androgen index (<jats:styled-content style=\"fixed-case\">FAI<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After intervention, mean serum 25(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)D was &gt;75.0\u00a0nmol\/L in cholecalciferol groups. However, the handgrip strength (29.7\u00a0\u00b1\u00a04.4, 29.3\u00a0\u00b1\u00a04.6, 30.6\u00a0\u00b1\u00a05.0 and 28.8\u00a0\u00b1\u00a04.3\u00a0kg, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.28) was comparable in the 4 groups. Subgroups analysis among subjects with baseline serum 25<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)D &lt; 25.0 and &lt;12.0\u00a0nmol\/L showed similar results. The mean serum testosterone decreased significantly at 6\u00a0months; however, delta change was similar in 4 groups. Change in handgrip strength and other outcomes was similar in 4 groups with and without adjustment for delta testosterone and <jats:styled-content style=\"fixed-case\">FAI<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Six months of cholecalciferol\/calcium supplementation had no significant effect on skeletal muscle strength and serum testosterone in young adult males.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13507","type":"journal-article","created":{"date-parts":[[2017,11,2]],"date-time":"2017-11-02T19:47:55Z","timestamp":1509652075000},"page":"217-226","source":"Crossref","is-referenced-by-count":38,"title":["Vitamin D and calcium supplementation, skeletal muscle strength and serum testosterone in young healthy adult males: Randomized control trial"],"prefix":"10.1111","volume":"88","author":[{"given":"Soma","family":"Saha","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism All India Institute 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