{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T05:49:37Z","timestamp":1788587377924,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T00:00:00Z","timestamp":1511913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Context<\/jats:title><jats:p>Abdominal visceral adiposity and central sarcopenia are markers of increased cardiovascular risk and mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess whether central sarcopenia and adiposity can serve as a marker of disease severity in patients with adrenal adenomas and glucocorticoid secretory autonomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>Twenty\u2010five patients with overt Cushing's syndrome (<jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content>), 48 patients with mild autonomous cortisol excess (<jats:styled-content style=\"fixed-case\">MACE<\/jats:styled-content>) and 32 patients with a nonfunctioning adrenal tumour (<jats:styled-content style=\"fixed-case\">NFAT<\/jats:styled-content>) were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medical records were reviewed, and body composition measurements (visceral fat [<jats:styled-content style=\"fixed-case\">VAT<\/jats:styled-content>], subcutaneous fat [<jats:styled-content style=\"fixed-case\">SAT<\/jats:styled-content>], visceral\/total fat [V\/T], visceral\/subcutaneous [V\/S] and total abdominal muscle mass) were calculated based on abdominal computed tomography (<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In patients with overt <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content>, when compared to patients with <jats:styled-content style=\"fixed-case\">NFAT<\/jats:styled-content>, the V\/T fat and the V\/S ratio were increased by 0.08 (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>.001) and by 0.3 (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>.001); however, these measurements were decreased by 0.04 (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.007) and 0.2 (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.01), respectively, in patients with <jats:styled-content style=\"fixed-case\">MACE<\/jats:styled-content>. Total muscle mass was decreased by \u221210\u00a0cm<jats:sup>2<\/jats:sup> (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.02) in patients with overt <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content> compared to patients with <jats:styled-content style=\"fixed-case\">NFAT<\/jats:styled-content>. Correlation with morning serum cortisol concentrations after dexamethasone suppression testing revealed that for every 28\u00a0nmol\/L cortisol increase there was a 0.008 increase in V\/T (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>.001), 0.02 increase in the V\/S fat ratio (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>.001) and a 1.2\u00a0cm<jats:sup>2<\/jats:sup> decrease in mean total muscle mass (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The severity of hypercortisolism was correlated with lower muscle mass and higher visceral adiposity. These <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>\u2010based markers may allow for a more reliable and objective assessment of glucocorticoid\u2010related disease severity in patients with adrenal adenomas.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13512","type":"journal-article","created":{"date-parts":[[2017,11,8]],"date-time":"2017-11-08T08:51:02Z","timestamp":1510131062000},"page":"209-216","source":"Crossref","is-referenced-by-count":61,"title":["Impact of hypercortisolism on skeletal muscle mass and adipose tissue mass in patients with adrenal adenomas"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4868-0423","authenticated-orcid":false,"given":"Danae A.","family":"Delivanis","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes, Metabolism, and Nutrition Mayo Clinic  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole M.","family":"I\u00f1iguez\u2010Ariza","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, Metabolism, and Nutrition Mayo Clinic  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad H.","family":"Zeb","sequence":"additional","affiliation":[{"name":"Division of Surgery Mayo Clinic  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Moynagh","sequence":"additional","affiliation":[{"name":"Department of Radiology Mayo Clinic  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Radiology Mayo Clinic  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Travis J.","family":"McKenzie","sequence":"additional","affiliation":[{"name":"Division of Surgery Mayo Clinic  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melinda A.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, Metabolism, and Nutrition Mayo Clinic  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charalambos","family":"Gogos","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University Hospital of Patras  Patras Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William F.","family":"Young","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, Metabolism, and Nutrition Mayo Clinic  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Bancos","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, Metabolism, and Nutrition Mayo Clinic  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venetsana","family":"Kyriazopoulou","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Metabolism University Hospital of Patras  Patras Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03344099"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.07.2799"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030254"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1323"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0000000000000151"},{"key":"e_1_2_7_7_1","first-page":"637","article-title":"A survey on adrenal incidentaloma in Italy. 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