{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T15:24:18Z","timestamp":1774538658284,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hyperandrogenism and exogenous glucocorticoid excess may cause unfavourable changes in the cardiovascular risk profile of patients with congenital adrenal hyperplasia (<jats:styled-content style=\"fixed-case\">CAH<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the cardiac function in paediatric patients with <jats:styled-content style=\"fixed-case\">CAH<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>Twenty\u2010seven paediatric patients with <jats:styled-content style=\"fixed-case\">CAH<\/jats:styled-content>, aged 8\u201016\u00a0years, were evaluated by physical examination, electrocardiogram (<jats:styled-content style=\"fixed-case\">ECG<\/jats:styled-content>), conventional echocardiography, tissue Doppler imaging and two\u2010dimensional (2D) myocardial strain (rate) imaging. Results were compared to 27 age\u2010 and gender\u2010 matched healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No signs of left ventricular hypertrophy or dilatation were detected on echocardiography. <jats:styled-content style=\"fixed-case\">ECG<\/jats:styled-content> revealed a high prevalence (25.9%) of incomplete right bundle branch block. Left ventricular posterior wall thickness in diastole (<jats:styled-content style=\"fixed-case\">LVPW<\/jats:styled-content>d) was significantly lower in patients with <jats:styled-content style=\"fixed-case\">CAH<\/jats:styled-content> compared to controls (5.55 vs 6.53\u00a0mm; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.009). The <jats:styled-content style=\"fixed-case\">LVPW<\/jats:styled-content>d Z\u2010score was significantly lower in patients with <jats:styled-content style=\"fixed-case\">CAH<\/jats:styled-content> yet within the normal range (\u22121.12 vs \u22120.35; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.002). Isovolumetric relaxation time was significantly lower in patients with <jats:styled-content style=\"fixed-case\">CAH<\/jats:styled-content> (49 vs 62\u00a0ms; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.003). Global longitudinal, radial and circumferential strain was not significantly different compared to controls. Global radial strain rate was significantly higher compared to healthy controls (2.58 vs 2.06 1\/s; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.046). Global longitudinal strain was negatively correlated with 24\u2010hour blood pressure parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cardiac evaluation of paediatric patients with <jats:styled-content style=\"fixed-case\">CAH<\/jats:styled-content> showed no signs of left ventricular hypertrophy or ventricular dilatation. <jats:styled-content style=\"fixed-case\">LVPW<\/jats:styled-content>d was lower in patients with <jats:styled-content style=\"fixed-case\">CAH<\/jats:styled-content> than in controls but within the normal range. A shorter isovolumetric relaxation time in patients with <jats:styled-content style=\"fixed-case\">CAH<\/jats:styled-content> may be a sign of mild left ventricular diastolic dysfunction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13529","type":"journal-article","created":{"date-parts":[[2017,12,12]],"date-time":"2017-12-12T03:48:47Z","timestamp":1513050527000},"page":"364-371","source":"Crossref","is-referenced-by-count":10,"title":["Cardiac function in paediatric patients with congenital adrenal hyperplasia due to 21 hydroxylase deficiency"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7977-6271","authenticated-orcid":false,"given":"Christiaan F.","family":"Mooij","sequence":"first","affiliation":[{"name":"Division of Pediatric Endocrinology Department of Pediatrics Amalia Children's Hospital Radboud University Medical Center  Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milanthy 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