{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T18:19:59Z","timestamp":1780597199064,"version":"3.54.1"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,1,4]],"date-time":"2018-01-04T00:00:00Z","timestamp":1515024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"Summary<\/jats:title>Objective<\/jats:title>The high prevalence of secondary hyperparathyroidism (SHPT<\/jats:styled-content>) after obesity surgery is a concern for long\u2010term bone health. Limited knowledge exists about optimal vitamin D and suppression of parathyroid hormone (PTH<\/jats:styled-content>) after these procedures. The aim of this study was to investigate the prevalence of SHPT<\/jats:styled-content> and its relation to vitamin D status.<\/jats:p><\/jats:sec>Design<\/jats:title>A cross\u2010sectional study at Oslo University Hospital, Norway.<\/jats:p><\/jats:sec>Patients<\/jats:title>A total of 502 consecutive patients, age 22\u201064\u00a0years, attending 2\u2010year follow\u2010up after Roux\u2010en\u2010Y gastric bypass.<\/jats:p><\/jats:sec>Measurements<\/jats:title>A serum intact PTH<\/jats:styled-content> >7.0\u00a0pmol\/L in the absence of elevated serum ionized calcium (iC<\/jats:styled-content>a) was considered as SHPT<\/jats:styled-content>. Vitamin D status was defined by serum concentrations of 25\u2010hydroxyvitamin D (S\u201025(OH<\/jats:styled-content>)D).<\/jats:p><\/jats:sec>Results<\/jats:title>Altogether, 171 patients (34%) had SHPT<\/jats:styled-content>. The prevalence of SHPT<\/jats:styled-content> varied across the range of S\u201025(OH<\/jats:styled-content>)D (P<\/jats:italic>\u00a0<\u00a00.001), being highest (71%) with S\u201025(OH<\/jats:styled-content>)D\u00a0<\u00a025\u00a0nmol\/L. Compared with S\u201025(OH<\/jats:styled-content>)D\u00a0<\u00a050\u00a0nmol\/L, the prevalence of SHPT<\/jats:styled-content> was lower with S\u201025(OH<\/jats:styled-content>)D\u00a0\u2265\u00a050\u00a0nmol\/L (29.0%; RR<\/jats:styled-content>\u00a0=\u00a00.64 (95%\u2010CI<\/jats:styled-content>:0.50\u20100.81)) and S\u201025(OH<\/jats:styled-content>)D\u00a0\u2265\u00a075\u00a0nmol\/L (27.7%; RR<\/jats:styled-content>\u00a0=\u00a00.61 (95%\u2010CI<\/jats:styled-content>:0.44\u20100.84)). S\u201025(OH<\/jats:styled-content>)D\u00a0\u2265 100\u00a0nmol\/L was associated with the lowest PTH<\/jats:styled-content> and the lowest prevalence of SHPT<\/jats:styled-content> (16.0%; RR<\/jats:styled-content>\u00a0=\u00a00.35 (95%\u2010CI<\/jats:styled-content>:0.14\u20100.88) compared with S\u201025(OH<\/jats:styled-content>)D\u00a0<\u00a050\u00a0nmol\/L) and the most normal calcium distribution. These associations were most pronounced with iC<\/jats:styled-content>a in the lower range. A synergistic association was found for S\u201025(OH<\/jats:styled-content>)D and iC<\/jats:styled-content>a on SHPT.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Vitamin D deficient patients had the highest prevalence of SHPT<\/jats:styled-content> 2\u00a0years after gastric bypass. PTH<\/jats:styled-content> and the prevalence of SHPT<\/jats:styled-content> were notably lower with S\u201025(OH<\/jats:styled-content>)D\u00a0\u2265\u00a0100\u00a0nmol\/L, compared with lower target levels.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13531","type":"journal-article","created":{"date-parts":[[2017,12,13]],"date-time":"2017-12-13T07:07:05Z","timestamp":1513148825000},"page":"372-379","source":"Crossref","is-referenced-by-count":24,"title":["Relationships of serum 25\u2010hydroxyvitamin D, ionized calcium and parathyroid hormone after obesity surgery"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8900-8436","authenticated-orcid":false,"given":"Stephen","family":"Hewitt","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Morbid Obesity and Preventive Medicine Oslo\u00a0University Hospital Oslo Norway"},{"name":"Institute of Clinical Medicine University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erlend Tuseth","family":"Aasheim","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Morbid Obesity and Preventive Medicine Oslo\u00a0University Hospital Oslo Norway"},{"name":"Department of Health Management and Health Economics University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torgeir Thorson","family":"S\u00f8vik","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Oslo\u00a0University Hospital Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rgen","family":"Jahnsen","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine University of Oslo Oslo Norway"},{"name":"Department of Gastroenterology Akershus University Hospital L\u00f8renskog Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Kristinsson","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Morbid Obesity and Preventive Medicine Oslo\u00a0University Hospital Oslo Norway"},{"name":"Department of Gastrointestinal Surgery Oslo\u00a0University Hospital Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik Fink","family":"Eriksen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Morbid Obesity and Preventive Medicine Oslo\u00a0University Hospital Oslo Norway"},{"name":"Institute of Clinical Medicine University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Mala","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Morbid Obesity and Preventive Medicine Oslo\u00a0University Hospital Oslo Norway"},{"name":"Department of Gastrointestinal Surgery Oslo\u00a0University Hospital Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60460-8"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-015-1657-z"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2009.28"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20461"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533614552850"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2226"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-015-1724-5"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2012.48"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0b013e32835004dc"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655202753416876"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-013-1104-y"},{"key":"e_1_2_6_13_1","first-page":"353","article-title":"Five\u2010year outcomes after laparoscopic gastric bypass and laparoscopic duodenal switch in patients with body mass index of 50 to 60: a randomized clinical trial","volume":"26","author":"Risstad H","year":"2015","journal-title":"JAMA Surg"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2015.82"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2016.01.001"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-14-0158"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2015.12.004"},{"key":"e_1_2_6_18_1","volume-title":"Dietary Reference Intakes for Calcium and Vitamin D","author":"The Institute of Medicine. 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