{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T09:22:04Z","timestamp":1777195324370,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T00:00:00Z","timestamp":1515715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570802"],"award-info":[{"award-number":["81570802"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003345","name":"Chinese Academy of Meteorological Sciences","doi-asserted-by":"publisher","award":["2016\u2010I2M\u20103\u2010003"],"award-info":[{"award-number":["2016\u2010I2M\u20103\u2010003"]}],"id":[{"id":"10.13039\/501100003345","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Glucocorticoids (<jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>s) are the first\u2010line treatment for myasthenia gravis (<jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content>) and act as long\u2010term immunosuppressants. However, <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>s can induce osteoporosis and bone fractures. In this study, we evaluate the effects of oral alendronate and alfacalcidol, or alfacalcidol alone on the bone of Chinese patients with <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content> who will initiate treatment with <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and methods<\/jats:title><jats:p>A total of 75 patients were included in this 12\u2010month prospective, open\u2010label, single\u2010centre study. Patients with bone mineral density (<jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>) T\u2010score less than \u22121.0 at baseline were treated with 70\u00a0mg of alendronate per week. Patients with <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> T\u2010score greater than \u22121.0 at baseline were included in the alfacalcidol\u2010alone group. Patients in two groups were treated with 0.25\u00a0\u03bcg of alfacalcidol every other day and 600\u00a0mg of calcium daily.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 12\u00a0months of treatment, the mean <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> of lumbar spine, femoral neck and total hip increased by 3.4% (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.002), 1.8% (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.21) and 2.6% (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.02), respectively, in alendronate group. In alfacalcidol\u2010alone group, the mean <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> of lumbar spine, femoral neck and total hip decreased by 6.1%, 3.2% and 3.3%, respectively (all <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>.001 vs baseline).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We demonstrated for the first time that treatment with alendronate combined with alfacalcidol significantly increased <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>, decreased bone turnover biomarker levels and reduced the occurrence of hypercalciuria in a large cohort of Chinese patients with <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content> who initiated treatment with glucocorticoids. However, treatment with alfacalcidol alone failed to prevent bone loss in patients with <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content> receiving glucocorticoid therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13537","type":"journal-article","created":{"date-parts":[[2017,12,20]],"date-time":"2017-12-20T14:49:09Z","timestamp":1513781349000},"page":"380-387","source":"Crossref","is-referenced-by-count":7,"title":["Effects of alendronate and alfacalcidol on bone in patients with myasthenia gravis initiating glucocorticoids treatment"],"prefix":"10.1111","volume":"88","author":[{"given":"Fang","family":"Lv","sequence":"first","affiliation":[{"name":"Department of Endocrinology Key Laboratory of Endocrinology National Health and Family Planning Commission Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing 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